PMID- 29696962
OWN - NLM
STAT- MEDLINE
DCOM- 20181220
LR  - 20181220
IS  - 1827-1898 (Electronic)
IS  - 0031-0808 (Linking)
VI  - 60
IP  - 3
DP  - 2018 Sep
TI  - Alpha1-antitrypsin deficiency: what's new after European Respiratory Society 
      Statement.
PG  - 101-108
LID - 10.23736/S0031-0808.18.03450-X [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is a clinically under-recognized inherited 
      disorder affecting the lungs and the liver. The most common manifestations are 
      pulmonary emphysema, bronchiectasis and liver disease. The recent publication of 
      the European Respiratory Society statement on diagnosis and treatment of 
      pulmonary diseases has replaced the 2003 American Thoracic Society and European 
      Respiratory Society one. New outcome parameters have been introduced and 
      validated by observational and randomized clinical trials, and new information 
      about efficacy and safety of augmentation therapy have been published. In this 
      narrative review we have commented the crucial points of the new European 
      Respiratory Society statement on AATD, including a review of the literature on 
      liver involvement and treatments.
FAU - Patrucco, Filippo
AU  - Patrucco F
AD  - Division of Pulmonology, Cardiothoracic and Vascular Department, AOU Citta della 
      Salute e della Scienza, Turin, Italy - filippo_patrucco@hotmail.it.
FAU - Venezia, Ludovica
AU  - Venezia L
AD  - General and Specialistic Medical Department, Division of Gastroenterology, AOU 
      Citta della Salute e della Scienza, Turin, Italy.
FAU - Gavelli, Francesco
AU  - Gavelli F
AD  - Unit of Emergency Medicine, Department of Translational Medicine, AOU Maggiore 
      della Carita of Novara, University of Piemonte Orientale, Novara, Italy.
FAU - Pellicano, Rinaldo
AU  - Pellicano R
AD  - General and Specialistic Medical Department, Division of Gastroenterology, AOU 
      Citta della Salute e della Scienza, Turin, Italy.
FAU - Solidoro, Paolo
AU  - Solidoro P
AD  - Division of Pulmonology, Cardiothoracic and Vascular Department, AOU Citta della 
      Salute e della Scienza, Turin, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180424
PL  - Italy
TA  - Panminerva Med
JT  - Panminerva medica
JID - 0421110
RN  - 0 (Aerosols)
RN  - 0 (SERPINA1 protein, human)
RN  - 0 (alpha 1-Antitrypsin)
RN  - alpha-1-Antitrypsin Deficiency, Autosomal Recessive
SB  - IM
MH  - Administration, Inhalation
MH  - Aerosols
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Liver Diseases/complications
MH  - Lung
MH  - Lung Diseases/diagnosis/therapy
MH  - Lung Transplantation
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/therapy
MH  - Pulmonary Emphysema/diagnosis/therapy
MH  - Pulmonary Medicine/*methods
MH  - Societies, Medical
MH  - alpha 1-Antitrypsin/*administration & dosage/blood
MH  - alpha 1-Antitrypsin Deficiency/*diagnosis/*therapy
EDAT- 2018/04/27 06:00
MHDA- 2018/12/21 06:00
CRDT- 2018/04/27 06:00
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2018/12/21 06:00 [medline]
PHST- 2018/04/27 06:00 [entrez]
AID - S0031-0808.18.03450-X [pii]
AID - 10.23736/S0031-0808.18.03450-X [doi]
PST - ppublish
SO  - Panminerva Med. 2018 Sep;60(3):101-108. doi: 10.23736/S0031-0808.18.03450-X. Epub 
      2018 Apr 24.