PMID- 29697013
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20181018
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 27
IP  - 8
DP  - 2018 Jul
TI  - Long-term survival of kidney grafts in lupus nephritis: a Mexican cohort.
PG  - 1303-1311
LID - 10.1177/0961203318770527 [doi]
AB  - Kidney transplant for patients with lupus nephritis (LN) has satisfactory 
      outcomes in studies with short-term or mid-term follow up. Nevertheless, 
      information about long-term outcomes is scarce. We performed a retrospective 
      matched-pair cohort study in 74 LN recipients compared with 148 non-LN controls 
      matched by age, sex, immunosuppressive treatment, human leukocyte antigen (HLA) 
      matches, and transplant period in order to evaluate long-term outcomes of kidney 
      transplant in LN recipients. Matched pairs were predominantly females (83%), 
      median age at transplant surgery of 32 years (interquartile range 23-38 years), 
      and 66% received a graft from a living related donor. Among LN recipients, 5-, 
      10-, 15-, and 20-year graft survival was 81%, 79%, 57% and 51%, respectively, and 
      it was similar to that observed in controls (89%, 78%, 64%, and 56%, 
      respectively). Graft loss (27% vs. 21%, p = 0.24) and overall survival ( 
      p = 0.15) were not different between LN recipients and controls. Also, there was 
      no difference in episodes of immunological rejection, thrombosis, or infection. 
      Only six LN recipients had biopsy-proven lupus recurrence and three of them had 
      graft loss. In a cohort with a long follow up of kidney transplant recipients, LN 
      recipients had similar long-term graft survival and overall outcomes compared 
      with non-lupus recipients when predictors are matched between groups.
FAU - Ramirez-Sandoval, J C
AU  - Ramirez-Sandoval JC
AD  - 1 Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran.
FAU - Chavez-Chavez, H
AU  - Chavez-Chavez H
AD  - 1 Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran.
FAU - Wagner, M
AU  - Wagner M
AD  - 2 Department of Medicine, Weill Cornell Medical College, New York, United States.
FAU - Vega-Vega, O
AU  - Vega-Vega O
AD  - 1 Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran.
FAU - Morales-Buenrostro, L E
AU  - Morales-Buenrostro LE
AUID- ORCID: 0000-0002-7227-484X
AD  - 1 Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran.
FAU - Correa-Rotter, R
AU  - Correa-Rotter R
AD  - 1 Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran.
LA  - eng
PT  - Journal Article
DEP - 20180426
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Kaplan-Meier Estimate
MH  - *Kidney Transplantation
MH  - Lupus Nephritis/*mortality/*therapy
MH  - Male
MH  - Mexico
MH  - Retrospective Studies
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Kidney failure
OT  - kidney transplantation
OT  - lupus nephritis
OT  - patient outcome assessment
OT  - renal dialysis
OT  - treatment outcome
EDAT- 2018/04/27 06:00
MHDA- 2018/10/20 06:00
CRDT- 2018/04/27 06:00
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
PHST- 2018/04/27 06:00 [entrez]
AID - 10.1177/0961203318770527 [doi]
PST - ppublish
SO  - Lupus. 2018 Jul;27(8):1303-1311. doi: 10.1177/0961203318770527. Epub 2018 Apr 26.