PMID- 29698896 OWN - NLM STAT- MEDLINE DCOM- 20190115 LR - 20190115 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 116 DP - 2018 Jul TI - Perfluoroalkyl substances in umbilical cord serum and gestational and postnatal growth in a Chinese birth cohort. PG - 197-205 LID - S0160-4120(17)31781-6 [pii] LID - 10.1016/j.envint.2018.04.015 [doi] AB - Although animal studies have found that perfluoroalkyl substances (PFASs) affect gestational and postnatal growth, the epidemiological findings are limited and not in agreement. We explored the associations of PFAS concentrations in umbilical cord blood with gestational and postnatal growth in China. Three hundred thirty-seven singleton newborns and their mothers were recruited from November 2013 to December 2015 in Zhoukou City, China. Umbilical cord blood was collected to measure eleven PFASs by liquid chromatography-mass spectrometry. The index of gestational and postnatal growth contained fetal weight, length, and head circumference. These were obtained at birth and at the follow-up investigation (mean 19 months). Exposed to higher perfluorooctanoic acid (PFOA) were connected with reduced length at birth (p for trend = 0.01) and decreased postnatal weight (beta = -429.2 g; 95% CI: -858.4, -0.121 for 2nd VS. 1st). Exposed to perfluoroundecanoic acid (PFUdA) were positively associated with indications of gestational growth and postnatal growth (p for trend = 0.02 for birth length; p for trend = 0.04 for postnatal length). Exposed to higher perfluorododecanoic acid (PFDoA) were associated with lower birth weight (beta = -122.9 g, 95% CI: -244.7 to -1.2 for 2nd VS. 1st), but higher postnatal length (p for trend = 0.03). Neonates in the highest exposure group of per-fluorohexanesulfonate (PFHxS) showed decreased birth length (beta = -0.33 cm, 95% CI: -0.68 to -0.01, for 2nd VS. 1st), but increased postnatal head circumference (p for trend = 0.04). Increased PFOA concentrations was associated with shorter birth length only in girls (p for trend = 0.04), suggesting that the effect of PFASs on gestational growth were different between boys and girls. In utero exposure to PFASs may affect gestational and postnatal growth. CI - Copyright (c) 2018. Published by Elsevier Ltd. FAU - Cao, Wencheng AU - Cao W AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. FAU - Liu, Xiao AU - Liu X AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. FAU - Liu, Xiaofang AU - Liu X AD - Analytical Chemistry, School of Chemical and Environmental Engineering, Wuhan Institute of Technology, LiuFang Campus, No.206, Guanggu 1st road, Wuhan 430205, PR China; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. FAU - Zhou, Yan AU - Zhou Y AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. FAU - Zhang, Xiaotian AU - Zhang X AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. FAU - Tian, Haoyuan AU - Tian H AD - Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, PR China. FAU - Wang, Jin AU - Wang J AD - Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, PR China. FAU - Feng, Shixian AU - Feng S AD - Institute of Chronic and Non-Communicable Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Nongye Donglu South, Zhengzhou 450016, PR China. FAU - Wu, Yongning AU - Wu Y AD - The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (CFSA) and China National Center for Food Safety Risk Assessment, #7 Panjiayuan Nanli, Beijing 100021, PR China. FAU - Bhatti, Parveen AU - Bhatti P AD - Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA. FAU - Wen, Sheng AU - Wen S AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, PR China. Electronic address: wenshenggy@aliyun.com. FAU - Sun, Xin AU - Sun X AD - Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, PR China. Electronic address: sunxin@chinacdc.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180423 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Fluorocarbons) SB - IM MH - Birth Weight/*physiology MH - Child Development/*physiology MH - China/epidemiology MH - Cohort Studies MH - Female MH - Fetal Blood/*chemistry MH - Fluorocarbons/*analysis MH - Humans MH - Infant, Newborn MH - Maternal Exposure/*statistics & numerical data OTO - NOTNLM OT - Cord blood OT - Gestational growth OT - Perfluorohexane sulfonate OT - Perfluorooctanoic acid OT - Postnatal growth EDAT- 2018/04/27 06:00 MHDA- 2019/01/16 06:00 CRDT- 2018/04/27 06:00 PHST- 2017/10/17 00:00 [received] PHST- 2018/04/08 00:00 [revised] PHST- 2018/04/09 00:00 [accepted] PHST- 2018/04/27 06:00 [pubmed] PHST- 2019/01/16 06:00 [medline] PHST- 2018/04/27 06:00 [entrez] AID - S0160-4120(17)31781-6 [pii] AID - 10.1016/j.envint.2018.04.015 [doi] PST - ppublish SO - Environ Int. 2018 Jul;116:197-205. doi: 10.1016/j.envint.2018.04.015. Epub 2018 Apr 23.