PMID- 29698969
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20181120
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 98
IP  - 2
DP  - 2018
TI  - Endoscopic Ultrasound Features of Multiple Endocrine Neoplasia Type 1-Related 
      versus Sporadic Pancreatic Neuroendocrine Tumors: A Single-Center Retrospective 
      Study.
PG  - 112-118
LID - 10.1159/000487939 [doi]
AB  - AIM: Pancreatic neuroendocrine tumors (pNETs) can occur in patients with a 
      familial syndrome either as multiple endocrine neoplasia type 1 (MEN-1) or as 
      sporadic tumors. Endoscopic ultrasound (EUS) has become one of the first-line 
      investigations for pNET characterization. The ultrasonographic features of pNETs 
      may differ depending on the familial versus sporadic pathogenesis of the tumor. 
      Therefore, the EUS findings could help and direct the definition of a pNET with 
      an impact on the most appropriate diagnostic and therapeutic patient management. 
      METHODS: In this single-center retrospective study, we reviewed the EUS features 
      of 94 pNETs from 37 MEN-1 patients and 15 pNETs from 11 sporadic disease patients 
      at the time of their first EUS assessment. We analyzed the most relevant 
      morphological and ultrasonographic characteristics of the tumors and compared the 
      findings between the 2 patient groups. RESULTS: Patients with MEN-1 more likely 
      present with multiple pNETs than patients with sporadic disease. Sporadic pNETs 
      are usually much bigger than those due to MEN-1. Moreover, pNETs are more 
      heterogeneous in patients with sporadic disease than in those with MEN-1. No 
      statistical difference with regard to definition of the margins, morphology, and 
      vascularization of the pNETs appears between the 2 groups. CONCLUSIONS: Patients 
      with sporadic disease usually present with bigger and more heterogeneous pNETs 
      than patients with MEN-1, who tend to present with a higher number of lesions. 
      EUS can facilitate the precise characterization of a pNET, and the 
      ultrasonographic features of the lesion can help and distinguish MEN-1-related 
      versus sporadic disease.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Tamagno, Gianluca
AU  - Tamagno G
AD  - Division of Endocrinology and Diabetology, University Hospital, Philipp's 
      University, Marburg, Germany.
AD  - Department of Endocrinology/Diabetes Mellitus, Mater Misericordiae University 
      Hospital, Dublin, Ireland.
FAU - Scherer, Vanessa
AU  - Scherer V
AD  - Division of Endocrinology and Diabetology, University Hospital, Philipp's 
      University, Marburg, Germany.
FAU - Caimo, Alberto
AU  - Caimo A
AD  - School of Mathematical Sciences, Dublin Institute of Technology, Dublin, Ireland.
FAU - Bergmann, Simona R
AU  - Bergmann SR
AD  - Division of Endocrinology and Diabetology, University Hospital, Philipp's 
      University, Marburg, Germany.
FAU - Kann, Peter H
AU  - Kann PH
AD  - Division of Endocrinology and Diabetology, University Hospital, Philipp's 
      University, Marburg, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180426
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endosonography
MH  - Feasibility Studies
MH  - Humans
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging/pathology
MH  - Neuroendocrine Tumors/*diagnostic imaging/pathology
MH  - Pancreas/diagnostic imaging/pathology
MH  - Pancreatic Neoplasms/*diagnostic imaging/pathology
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - Young Adult
OTO - NOTNLM
OT  - Endoscopic ultrasound
OT  - Multiple endocrine neoplasia type 1
OT  - Neuroendocrine tumor
OT  - Pancreas
EDAT- 2018/04/27 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/04/27 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2018/02/25 00:00 [accepted]
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2018/04/27 06:00 [entrez]
AID - 000487939 [pii]
AID - 10.1159/000487939 [doi]
PST - ppublish
SO  - Digestion. 2018;98(2):112-118. doi: 10.1159/000487939. Epub 2018 Apr 26.