PMID- 29699021
OWN - NLM
STAT- MEDLINE
DCOM- 20181015
LR  - 20181023
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 36
IP  - 2
DP  - 2018 Feb 20
TI  - [Effect of ulinastatin on myocardial injury in patients with acute severe carbon 
      monoxide poisoning].
PG  - 154-156
LID - 10.3760/cma.j.issn.1001-9391.2018.02.020 [doi]
AB  - Objective: To observe the effect of ulinastatin on myocardial injury in patients 
      with acute severe carbon monoxide poisoning (ASCOP) . Methods: By using the 
      prospective study method, 123 cases of ASCOP patients admitted to our hospital, 
      were randomly divided into two groups. There were no significantly different 
      between the two groups in the abnormal rates of ECG, brain natriuretic peptide 
      (BNP) , troponin I (cTNI) , creatine phosphokinase (CK-MB) and creatine 
      phosphokinase (CK) . The control group according to the patients need to be 
      treated with hyperbaric oxygen and routine medical treatment; the observation 
      group was treated with ulinastatin 100 thousand u intravenous injection based on 
      routine treatment measures on Q8 h, the two groups were 7 d for the 1 course of 
      treatment. Compared two groups of patients after 3 days, 7 days of 
      electrocardiogram, brain natriuretic peptide (BNP) , troponin I (cTNI) , creatine 
      kinase isoenzyme (CK-MB) , creatine kinase (CK) , the case fatality rate within 
      14 days, and the abnormality rate of BNP, cTNI, CK-MB and Ck. Results: the 
      observation group for 3 days, 7 days, 14 days were abnormal, brain natriuretic 
      peptide (BNP) , cardiac troponin I (cTNI) , creatine kinase isoenzyme (CK-MB) , 
      creatine kinase (CK) the average results were significantly lower than those in 
      the control group (P<0.05) ; The 14 d BNP in the observation group was 
      significantly lower than the control group (P<0. 05) ; the case fatality rateof 
      observation group was lower than the control group within 14 days (1.2% vs 3.3%) 
      . Conclusion: Ulinastatin can significantly improve the ASCOP to reduce the 
      damage to the heart, reduce the case fatality rateand improve the prognosis.
FAU - Wang, P
AU  - Wang P
AD  - Emergency Department of Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui 053000, China.
FAU - Li, W
AU  - Li W
FAU - Yang, J L
AU  - Yang JL
FAU - Wang, Y
AU  - Wang Y
FAU - Liu, Q
AU  - Liu Q
FAU - Wang, W Z
AU  - Wang WZ
FAU - Qi, H N
AU  - Qi HN
FAU - Li, J
AU  - Li J
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 0 (Biomarkers)
RN  - 0 (Glycoproteins)
RN  - 0 (Troponin I)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
RN  - OR3S9IF86U (urinastatin)
SB  - IM
MH  - Acute Disease
MH  - Biomarkers
MH  - Carbon Monoxide Poisoning/*complications
MH  - Creatine Kinase/blood
MH  - Creatine Kinase, MB Form/blood
MH  - Electrocardiography
MH  - Glycoproteins/*pharmacology/therapeutic use
MH  - Heart Injuries/*drug therapy
MH  - Humans
MH  - Natriuretic Peptide, Brain/blood
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Troponin I/blood
OTO - NOTNLM
OT  - Ulinastatin
OT  - acute carbon monoxide poisoning
OT  - myocardial damage
OT  - prognosis
EDAT- 2018/04/28 06:00
MHDA- 2018/10/16 06:00
CRDT- 2018/04/27 06:00
PHST- 2018/04/27 06:00 [entrez]
PHST- 2018/04/28 06:00 [pubmed]
PHST- 2018/10/16 06:00 [medline]
AID - 10.3760/cma.j.issn.1001-9391.2018.02.020 [doi]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Feb 20;36(2):154-156. doi: 
      10.3760/cma.j.issn.1001-9391.2018.02.020.