PMID- 29700574
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20190102
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 33
IP  - 11
DP  - 2018 Nov
TI  - Serum brain-derived neurotrophic factor level and exercise tolerance complement 
      each other in predicting the prognosis of patients with heart failure.
PG  - 1325-1333
LID - 10.1007/s00380-018-1174-9 [doi]
AB  - Brain-derived neurotropic factor (BDNF) is a myokine that plays a key role in 
      regulating survival, growth, and maintenance of neurons. We investigated whether 
      the serum BDNF level at discharge could predict the prognosis in patients with 
      heart failure (HF). Furthermore, we aimed to examine the relationship between 
      this myokine and exercise tolerance. We prospectively enrolled 94 patients who 
      were hospitalized for worsening HF and had cardiac rehabilitation. At discharge, 
      the serum BDNF level of all patients was measured using a commercial ELISA kit 
      and they underwent a cardiopulmonary exercise test to measure peak oxygen uptake 
      (peak VO(2)). Correlation was not observed between BDNF and peak VO(2). 
      Kaplan-Meier analysis demonstrated that cardiac death or rehospitalization owing 
      to worsening HF was significantly higher in the low BDNF group (p = 0.023). The 
      combination of peak VO(2) and BDNF levels led to the identification of subgroups 
      with significantly different probabilities of events (p = 0.005). In particular, 
      in the low BDNF and low peak VO(2) group, the frequency of rehospitalization 
      within half a year after discharge was much higher than that in other groups. 
      Multivariate analysis found BDNF as an independent factor of adverse events 
      (hazard ratio 0.956; 95% confidence interval 0.911-0.999; p = 0.046). The serum 
      BDNF level at discharge may be a useful biomarker of the prognosis in patients 
      with HF. Furthermore, combining BDNF and peak VO(2) may be useful for predicting 
      early cardiac events.
FAU - Shibata, Atsushi
AU  - Shibata A
AD  - Department of Cardiovascular Medicine, Osaka City University Graduate School of 
      Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Hanatani, Akihisa
AU  - Hanatani A
AUID- ORCID: 0000-0003-1014-7447
AD  - Department of Cardiovascular Medicine, Osaka City University Graduate School of 
      Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. 
      hanatania@msic.med.osaka-cu.ac.jp.
FAU - Izumi, Yasukatsu
AU  - Izumi Y
AD  - Department of Internal Medicine, Takaishikamo Hospital, Osaka, Japan.
FAU - Kitada, Ryoko
AU  - Kitada R
AD  - Department of Cardiovascular Medicine, Osaka City University Graduate School of 
      Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Iwata, Shinichi
AU  - Iwata S
AD  - Department of Cardiovascular Medicine, Osaka City University Graduate School of 
      Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Yoshiyama, Minoru
AU  - Yoshiyama M
AD  - Department of Cardiovascular Medicine, Osaka City University Graduate School of 
      Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180426
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/mortality/*physiopathology
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/*physiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume/*physiology
MH  - Survival Rate/trends
OTO - NOTNLM
OT  - Brain-derived neurotropic factor
OT  - Exercise tolerance
OT  - Heart failure
OT  - Myokines
OT  - Prognosis
EDAT- 2018/04/28 06:00
MHDA- 2019/01/03 06:00
CRDT- 2018/04/28 06:00
PHST- 2018/01/29 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/04/28 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
PHST- 2018/04/28 06:00 [entrez]
AID - 10.1007/s00380-018-1174-9 [pii]
AID - 10.1007/s00380-018-1174-9 [doi]
PST - ppublish
SO  - Heart Vessels. 2018 Nov;33(11):1325-1333. doi: 10.1007/s00380-018-1174-9. Epub 
      2018 Apr 26.