PMID- 2970309
OWN - NLM
STAT- MEDLINE
DCOM- 19881005
LR  - 20190720
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 115
IP  - 2
DP  - 1988 Sep
TI  - Activation of antigen-specific suppressor T cells by the intravenous injection of 
      soluble blood-stage malarial antigen.
PG  - 437-46
AB  - The regulation of delayed-type hypersensitivity (DTH) to soluble antigens derived 
      from blood-stage parasites was investigated. DTH responses to soluble blood-stage 
      malarial antigen were induced by subcutaneous (sc) sensitization in the flanks 
      and elicited by ear challenge with the same antigen 6 days later. Adoptive 
      transfer studies revealed that T cells of the L3T4+ phenotype were mediating this 
      response. When a high dose of malarial antigen was injected intravenously (iv) 
      prior to sc sensitization, immunosuppression of DTH resulted. The degree of 
      immunosuppression was dependent on the dose of antigen injected iv and the time 
      at which it was administered prior to sc sensitization. Immunosuppression was 
      antigen-specific and mediated by Lyt-2+ splenic T cells.
FAU - Russo, D M
AU  - Russo DM
AD  - Department of Microbiology and Immunology, Hahnemann University, Philadelphia, 
      Pennsylvania 19102.
FAU - Weidanz, W P
AU  - Weidanz WP
LA  - eng
GR  - AI12710/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (Antigens, Protozoan)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation, T-Lymphocyte/analysis
MH  - Antigens, Protozoan/administration & dosage/*immunology
MH  - Hypersensitivity, Delayed/*immunology
MH  - *Immunity, Cellular
MH  - Immunization, Passive
MH  - Injections, Intravenous
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasmodium/*immunology
MH  - Solubility
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
AID - 0008-8749(88)90196-7 [pii]
AID - 10.1016/0008-8749(88)90196-7 [doi]
PST - ppublish
SO  - Cell Immunol. 1988 Sep;115(2):437-46. doi: 10.1016/0008-8749(88)90196-7.