PMID- 2970390
OWN - NLM
STAT- MEDLINE
DCOM- 19880929
LR  - 20190813
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 147
IP  - 5
DP  - 1988 Jun
TI  - Clonal variation in childhood acute lymphoblastic leukaemia at early and late 
      relapse detected by analyses of phenotype and genotype.
PG  - 503-7
AB  - To increase our knowledge of the clonal relationship of leukaemia relapse, the 
      genotypes and phenotypes of ten children with acute lymphoblastic leukaemia (ALL) 
      were examined at initial diagnosis and relapse. Seven patients were phenotyped as 
      common ALL, two as mixed, and one as T-cell ALL (T-ALL). Comparative analyses of 
      immunoglobulin (Ig) heavy and light chain as well as T-cell receptor beta-chain 
      (T beta) sequences revealed clonal variations, i.e. appearance of a novel or an 
      evoluted leukaemic cell clone in five patients coinciding with the loss of common 
      acute lymphoblastic leukaemic antigen (CALLA) in four cases, irrespective of 
      early or late relapse. Conversion of early B- to T-ALL or lymphoblastic to 
      non-lymphoblastic leukaemia was not noted in any of the patients examined. Our 
      results suggest that clonal variation is a frequent event in childhood ALL.
FAU - Raghavachar, A
AU  - Raghavachar A
AD  - Department of Transfusion Medicine, University of Ulm, Federal Republic of 
      Germany.
FAU - Ludwig, W D
AU  - Ludwig WD
FAU - Bartram, C R
AU  - Bartram CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Immunoglobulins)
RN  - 0 (Lewis X Antigen)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Antigens, Differentiation/analysis
MH  - Antigens, Neoplasm/analysis/*genetics
MH  - B-Lymphocytes
MH  - Child
MH  - Clone Cells
MH  - Genotype
MH  - Humans
MH  - Immunoglobulins/genetics
MH  - Leukemia, Lymphoid/*genetics/immunology/pathology
MH  - Lewis X Antigen/analysis/genetics
MH  - Neprilysin
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell/analysis/*genetics
MH  - Recurrence
MH  - T-Lymphocytes
EDAT- 1988/06/01 00:00
MHDA- 1988/06/01 00:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 1988/06/01 00:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
AID - 10.1007/BF00441975 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1988 Jun;147(5):503-7. doi: 10.1007/BF00441975.