PMID- 29704512
OWN - NLM
STAT- MEDLINE
DCOM- 20190604
LR  - 20190604
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 140
DP  - 2018 Jun
TI  - The effect of the anodal transcranial direct current stimulation over the 
      cerebellum on the motor cortex excitability.
PG  - 114-119
LID - S0361-9230(18)30120-5 [pii]
LID - 10.1016/j.brainresbull.2018.04.012 [doi]
AB  - This study was designed to investigate whether the cerebellum has an inhibitory 
      effect on motor cortical excitability. Sixteen healthy adults (age range, 25-50 
      years, five female) participated in the study. Anodal cerebellar transcranial 
      direct current stimulation (a-cTDCS) was used to modulate cerebellar 
      excitability. A-cTDCS was given for 20 min at 1 mA intensity. The automatic 
      threshold tracking method was used to investigate cortical excitability. Resting 
      motor threshold (RMT), short interval intracortical inhibition (SICI), short 
      interval intracortical facilitation (SICF), intracortical facilitation (ICF), and 
      the input output curve (I-O curve) were motor cortical excitability parameters. 
      a-cTDCS caused a reduction in overall SICI and the reduced SICF for interstimulus 
      intervals (ISIs) to 2.4-4.4 ms. a-cTDCS has no effect on ICF, RMT, and the I-O 
      curve. There were no significant changes in any of these cortical excitability 
      parameters after sham cTDCS. Results of the study indicate that a-cTDCS has a 
      dual (both inhibitory and excitatory) effect on motor cortical excitability, 
      rather than a simple inhibitory effect. The cerebellum modulates both the 
      inhibitory and facilitatory activities of motor cortex (M1) and suggest that 
      cerebello-cerebral motor connectivity is more complex than solely inhibitory or 
      facilitatory connections.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Ates, Mehlika Panpalli
AU  - Ates MP
AD  - Department of Neurology, University of Health Sciences, Diskapi Yildirim Beyazit 
      Educational and Research Hospital, Ankara, Turkey. Electronic address: 
      muefhulkika@gmail.com.
FAU - Alaydin, Halil Can
AU  - Alaydin HC
AD  - Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
FAU - Cengiz, Bulent
AU  - Cengiz B
AD  - Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey; 
      Motor Control Laboratory, The Clinical Neurophysiology Division of the Department 
      of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180425
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
MH  - Adult
MH  - Cerebellum/*physiology
MH  - Electromyography
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Neural Pathways/physiology
MH  - *Transcranial Direct Current Stimulation
OTO - NOTNLM
OT  - Automatic threshold tracking
OT  - Cerebellar transcranial direct current stimulation
OT  - Motor cortical excitability
OT  - Transcranial magnetic stimulation
EDAT- 2018/04/29 06:00
MHDA- 2019/06/05 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/02/20 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2019/06/05 06:00 [medline]
PHST- 2018/04/29 06:00 [entrez]
AID - S0361-9230(18)30120-5 [pii]
AID - 10.1016/j.brainresbull.2018.04.012 [doi]
PST - ppublish
SO  - Brain Res Bull. 2018 Jun;140:114-119. doi: 10.1016/j.brainresbull.2018.04.012. 
      Epub 2018 Apr 25.