PMID- 29704558
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 49
DP  - 2018 Aug
TI  - Genome-wide association studies in kidney transplantation: Advantages and 
      constraints.
PG  - 1-4
LID - S0966-3274(18)30048-0 [pii]
LID - 10.1016/j.trim.2018.04.004 [doi]
AB  - Since the discovery of the human leukocyte antigen (HLA) system, the role of HLA 
      molecules in the field of transplantation has been appreciated: better matching 
      leads to better graft function. Since then, the association of other genetic 
      polymorphisms with clinical outcome has been investigated in many studies. 
      Genome-wide association studies (GWAS) represent a powerful tool to identify 
      causal genetic variants, by simultaneously analyzing millions of single 
      nucleotide polymorphisms scattered across the genome. GWAS in transplantation may 
      indeed be useful to reveal novel markers that may potentially be involved in the 
      mechanism of allograft rejection and graft failure. However, the relevance of 
      GWAS for risk stratification or donor selection for an individual patient is 
      limited as is already reflected by the fact that many parameters, significant in 
      one study, cannot be confirmed in another one.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yang, Jianxin
AU  - Yang J
AD  - Dept. of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Claas, Frans H J
AU  - Claas FHJ
AD  - Dept. of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Eikmans, Michael
AU  - Eikmans M
AD  - Dept. of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands. Electronic address: M.Eikmans@lumc.nl.
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180425
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Genome-Wide Association Study
MH  - Graft Rejection/*genetics/immunology
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - *Kidney Transplantation
MH  - Patient Selection
MH  - Polymorphism, Genetic
MH  - Precision Medicine
MH  - Risk
OTO - NOTNLM
OT  - Genome-wide association studies
OT  - Kidney transplantation
EDAT- 2018/04/29 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/04/29 06:00
PHST- 2018/04/22 00:00 [received]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/04/29 06:00 [entrez]
AID - S0966-3274(18)30048-0 [pii]
AID - 10.1016/j.trim.2018.04.004 [doi]
PST - ppublish
SO  - Transpl Immunol. 2018 Aug;49:1-4. doi: 10.1016/j.trim.2018.04.004. Epub 2018 Apr 
      25.