PMID- 29704567
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20191219
IS  - 1089-8611 (Electronic)
IS  - 1089-8603 (Print)
IS  - 1089-8603 (Linking)
VI  - 77
DP  - 2018 Jul 1
TI  - Physiological activation and deactivation of soluble guanylate cyclase.
PG  - 65-74
LID - S1089-8603(18)30053-3 [pii]
LID - 10.1016/j.niox.2018.04.011 [doi]
AB  - Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous 
      signaling molecule nitric oxide (NO) into the ubiquitous secondary signaling 
      messenger cyclic guanosine monophosphate in eukaryotic organisms. sGC is 
      exquisitely tuned to respond to low levels of NO, allowing cells to respond to 
      non-toxic levels of NO. In this review, the structure of sGC is discussed in the 
      context of sGC activation and deactivation. The sequence of events in the 
      activation pathway are described into a comprehensive model of in vivo sGC 
      activation as elucidated both from studies with purified enzyme and those done in 
      cells. This model is then used to discuss the deactivation of sGC, as well as the 
      molecular mechanisms of pathophysiological deactivation.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Horst, Benjamin G
AU  - Horst BG
AD  - Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
FAU - Marletta, Michael A
AU  - Marletta MA
AD  - Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA; 
      Department of Molecular and Cell Biology, University of California, Berkeley, 
      Berkeley, CA, USA; California Institute for Quantitative Biosciences, University 
      of California, Berkeley, Berkeley, CA, USA. Electronic address: 
      marletta@berkeley.edu.
LA  - eng
GR  - T32 GM066698/GM/NIGMS NIH HHS/United States
GR  - T32 GM066698/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20180425
PL  - United States
TA  - Nitric Oxide
JT  - Nitric oxide : biology and chemistry
JID - 9709307
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 4.6.1.2 (Soluble Guanylyl Cyclase)
SB  - IM
MH  - Animals
MH  - Enzyme Activation
MH  - Humans
MH  - Nitric Oxide/metabolism
MH  - Signal Transduction
MH  - Soluble Guanylyl Cyclase/*metabolism
PMC - PMC6919197
MID - NIHMS1062258
OTO - NOTNLM
OT  - Allosteric activation
OT  - Heme cofactor
OT  - Nitric oxide
OT  - Soluble guanylate cyclase
COIS- Conflicts of interest The authors declare no competing financial interests.
EDAT- 2018/04/29 06:00
MHDA- 2019/04/04 06:00
PMCR- 2019/12/18
CRDT- 2018/04/29 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/04/23 00:00 [revised]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/04/29 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2018/04/29 06:00 [entrez]
PHST- 2019/12/18 00:00 [pmc-release]
AID - S1089-8603(18)30053-3 [pii]
AID - 10.1016/j.niox.2018.04.011 [doi]
PST - ppublish
SO  - Nitric Oxide. 2018 Jul 1;77:65-74. doi: 10.1016/j.niox.2018.04.011. Epub 2018 Apr 
      25.