PMID- 29705838
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20190716
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 256
IP  - 8
DP  - 2018 Aug
TI  - Potential predictors for frequent relapse in human leukocyte 
      antigen-B27-associated uveitis.
PG  - 1543-1549
LID - 10.1007/s00417-018-4002-0 [doi]
AB  - PURPOSE: To identify potential predictors for frequent relapse in a cohort of 
      patients with human leukocyte antigen (HLA)-B27-associated uveitis in a tertiary 
      referral center at the initial visit. METHODS: This retrospective cohort study 
      comprised 130 patients diagnosed with HLA-B27-associated uveitis. Subjects were 
      divided into two groups according to the frequency of uveitis attacks 
      (number/year): frequent relapse (FR) (who relapsed more than twice a year, 38) 
      and infrequent relapse (IR) group (who relapsed twice or less than twice a year, 
      92). RESULTS: The FR group presented more often with hypopyon or posterior 
      synechiae at the initial presentation. Interestingly, posterior segment 
      involvements including vitritis, vasculitis, or cystoid macular edema were not 
      significantly different between the groups. In terms of laboratory findings, the 
      erythrocyte sedimentation rate (ESR) was higher in the FR group. Multivariate Cox 
      hazards analysis showed male sex, the presence of hypopyon, and ESR to be 
      potential predictive factors for frequent relapse. CONCLUSION: We found that male 
      sex, hypopyon at presentation, and high ESR are potential predictors for frequent 
      relapse in HLA-B27-associated uveitis. Identifying patients at higher risk of 
      relapse could provide important information for patients, allowing patients to 
      understand their condition and increase their acceptance of strict management.
FAU - Kim, Mirinae
AU  - Kim M
AD  - Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, 222 Banpo-daero, 
      Seocho-gu, Seoul, 06591, Republic of Korea.
FAU - Sim, Yoon Seob
AU  - Sim YS
AD  - Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, 222 Banpo-daero, 
      Seocho-gu, Seoul, 06591, Republic of Korea.
FAU - Choi, Seung Yong
AU  - Choi SY
AD  - Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, 222 Banpo-daero, 
      Seocho-gu, Seoul, 06591, Republic of Korea.
FAU - Park, Young-Hoon
AU  - Park YH
AD  - Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, 222 Banpo-daero, 
      Seocho-gu, Seoul, 06591, Republic of Korea. parkyh@catholic.ac.kr.
AD  - Catholic Institute for Visual Science, College of Medicine, The Catholic 
      University of Korea, Seoul, Republic of Korea. parkyh@catholic.ac.kr.
LA  - eng
GR  - 2016R1A6A1A03010528/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20180429
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Recurrence
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - *Risk Assessment
MH  - Tomography, Optical Coherence
MH  - Uveitis, Anterior/diagnosis/epidemiology/*immunology
MH  - Visual Acuity
MH  - Young Adult
OTO - NOTNLM
OT  - Anterior uveitis
OT  - ESR
OT  - HLA-B27
OT  - Hypopyon
OT  - Relapse
OT  - Uveitis
EDAT- 2018/05/01 06:00
MHDA- 2018/07/24 06:00
CRDT- 2018/04/30 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2018/04/30 06:00 [entrez]
AID - 10.1007/s00417-018-4002-0 [pii]
AID - 10.1007/s00417-018-4002-0 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2018 Aug;256(8):1543-1549. doi: 
      10.1007/s00417-018-4002-0. Epub 2018 Apr 29.