PMID- 29705927
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20181114
IS  - 2190-3883 (Electronic)
IS  - 1234-1983 (Print)
IS  - 1234-1983 (Linking)
VI  - 59
IP  - 3
DP  - 2018 Aug
TI  - Single nucleotide polymorphism rs11614913 associated with CC genotype in 
      miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not 
      salivary gland tumors in Polish population.
PG  - 301-304
LID - 10.1007/s13353-018-0445-6 [doi]
AB  - The miRNA-196a2 has shown significance in the development of various neoplasms, 
      including head and neck squamous cell carcinoma (HNSCC). The oncogenic 
      functionality of this miRNA is mediated via its potential to target annexin A1 
      mRNA, a tumor suppressor gene involved in inhibition of the NF-kappaB pathway. 
      Interestingly, recent data indicate a susceptibility for aforementioned neoplasms 
      in patients with the CC genotype vs the CT and TT genotypes of the rs11614913 SNP 
      located within the DNA sequence of the miR-196a2 that results in elevated 
      expression of the gene. To further investigate this phenomenon, we genotyped this 
      SNP in 40 patients with laryngeal squamous cell carcinoma (LSCC), the most common 
      tumor of the head and neck region and 60 patients with salivary gland tumors 
      (SGT) that show a yet unexplained incidence increase in the last two decades. In 
      agreement with previous reports, we have identified a statistically significant 
      (p < 0.05) overrepresentation of the CC genotype in LSCC patients and 
      demonstrated in LSCC cell lines that it results in elevated expression of 
      miR-196a2 as compared to cell lines with the TT genotype of the respective SNP. 
      Importantly, none of these correlations was found in patients with SGT. These 
      findings underline the importance of the SNP rs11614913 for LSCC development in 
      the Polish population and moreover highlight the different genetic background of 
      the two studied neoplasms of the head and neck region.
FAU - Skalski, Marcin
AU  - Skalski M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
FAU - Ustaszewski, Adam
AU  - Ustaszewski A
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
FAU - Jaskiewicz, Katarzyna
AU  - Jaskiewicz K
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
FAU - Kiwerska, Katarzyna
AU  - Kiwerska K
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
AD  - Department of Tumor Pathology, Greater Poland Cancer Center, Poznan, Poland.
FAU - Wierzbicka, Malgorzata
AU  - Wierzbicka M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
AD  - Department of Otolaryngology and Laryngological Oncology, Poznan University of 
      Medical Sciences, Poznan, Poland.
FAU - Klimza, Hanna
AU  - Klimza H
AD  - Department of Otolaryngology and Laryngological Oncology, Poznan University of 
      Medical Sciences, Poznan, Poland.
FAU - Grenman, Reidar
AU  - Grenman R
AD  - Department of Otorhinolaryngology - Head and Neck Surgery and Department of 
      Medical Biochemistry, Turku University Hospital and University of Turku, Turku, 
      Finland.
FAU - Giefing, Maciej
AU  - Giefing M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland. 
      maciej.giefing@igcz.poznan.pl.
AD  - Department of Otolaryngology and Laryngological Oncology, Poznan University of 
      Medical Sciences, Poznan, Poland. maciej.giefing@igcz.poznan.pl.
LA  - eng
GR  - 2016/23/B/NZ2/03041/Narodowe Centrum Nauki/
PT  - Journal Article
DEP - 20180429
PL  - England
TA  - J Appl Genet
JT  - Journal of applied genetics
JID - 9514582
RN  - 0 (MIRN196 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - MicroRNAs/*genetics
MH  - Poland
MH  - *Polymorphism, Single Nucleotide
MH  - Salivary Gland Neoplasms/genetics
MH  - Sequence Analysis, DNA
PMC - PMC6060993
OTO - NOTNLM
OT  - Genotyping
OT  - LSCC
OT  - Salivary gland tumor
OT  - miRNA-196-a2
OT  - rs11614913
COIS- All procedures performed in studies involving human participants were in 
      accordance with the ethical standards of the institutional and/or national 
      research committee and with the 1964 Helsinki declaration and its later 
      amendments or comparable ethical standards. CONFLICT OF INTEREST: The authors 
      declare that they have no conflict of interests. ETHICS APPROVAL: Approval of the 
      ethics institutional review board at the University of Medical Sciences in 
      Poznan, Poland (No. 449/17). Informed consent was obtained from all subjects.
EDAT- 2018/05/01 06:00
MHDA- 2018/10/20 06:00
PMCR- 2018/04/29
CRDT- 2018/04/30 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/04/12 00:00 [revised]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
PHST- 2018/04/30 06:00 [entrez]
PHST- 2018/04/29 00:00 [pmc-release]
AID - 10.1007/s13353-018-0445-6 [pii]
AID - 445 [pii]
AID - 10.1007/s13353-018-0445-6 [doi]
PST - ppublish
SO  - J Appl Genet. 2018 Aug;59(3):301-304. doi: 10.1007/s13353-018-0445-6. Epub 2018 
      Apr 29.