PMID- 29706134
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 20
IP  - 1
DP  - 2018 Apr 30
TI  - Additive value of 3T cardiovascular magnetic resonance coronary angiography for 
      detecting coronary artery disease.
PG  - 29
LID - 10.1186/s12968-018-0450-2 [doi]
LID - 29
AB  - BACKGROUND: The purpose of the work was to evaluate the incremental diagnostic 
      value of free-breathing, contrast-enhanced, whole-heart, 3 T cardiovascular 
      magnetic resonance coronary angiography (CE-MRCA) to stress/rest myocardial 
      perfusion imaging (MPI) and late gadolinium enhancement (LGE) imaging for 
      detecting coronary artery disease (CAD). METHODS: Fifty-one patients with 
      suspected CAD underwent a comprehensive cardiovascular magnetic resonance (CMR) 
      examination (CE-MRCA, MPI, and LGE). The additive diagnostic value of MRCA to MPI 
      and LGE was evaluated using invasive x-ray coronary angiography (XA) as the 
      standard for defining functionally significant CAD (>/= 50% stenosis in vessels 
      > 2 mm in diameter). RESULTS: 90.2% (46/51) patients (54.0 +/- 11.5 years; 71.7% 
      men) completed CE-MRCA successfully. On per-patient basis, compared to MPI/LGE 
      alone or MPI alone, the addition of MRCA resulted in higher sensitivity (100% vs. 
      76.5%, p < 0.01), no change in specificity (58.3% vs. 66.7%, p = 0.6), and higher 
      accuracy (89.1% vs 73.9%, p < 0.01) for CAD detection (prevalence = 73.9%). 
      Compared to LGE alone, the addition of CE-MRCA resulted in higher sensitivity 
      (97.1% vs. 41.2%, p < 0.01), inferior specificity (83.3% vs. 91.7%, p = 0.02), 
      and higher diagnostic accuracy (93.5% vs. 54.3%, p < 0.01). CONCLUSION: The 
      inclusion of successful free-breathing, whole-heart, 3 T CE-MRCA significantly 
      improved the sensitivity and diagnostic accuracy as compared to MPI and LGE alone 
      for CAD detection.
FAU - Zhang, Lijun
AU  - Zhang L
AD  - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 
      Anzhenli Avenue, Chao Yang District, Beijing, 100029, China.
FAU - Song, Xiantao
AU  - Song X
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing, China.
FAU - Dong, Li
AU  - Dong L
AD  - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 
      Anzhenli Avenue, Chao Yang District, Beijing, 100029, China.
FAU - Li, Jianan
AU  - Li J
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing, China.
FAU - Dou, Ruiyu
AU  - Dou R
AD  - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 
      Anzhenli Avenue, Chao Yang District, Beijing, 100029, China.
FAU - Fan, Zhanming
AU  - Fan Z
AD  - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 
      Anzhenli Avenue, Chao Yang District, Beijing, 100029, China. fanzm120@126.com.
FAU - An, Jing
AU  - An J
AD  - Siemens Shenzhen Magnetic Resonance Ltd, Guangdong Shenzhen, China.
FAU - Li, Debiao
AU  - Li D
AD  - Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, University of 
      California, Los Angeles, USA.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180430
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media/administration & dosage
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*diagnostic imaging/physiopathology
MH  - Coronary Circulation
MH  - Coronary Stenosis/*diagnostic imaging/physiopathology
MH  - Coronary Vessels/*diagnostic imaging/physiopathology
MH  - Female
MH  - Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/*methods
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Severity of Illness Index
PMC - PMC5925832
OTO - NOTNLM
OT  - 3 Tesla
OT  - Contrast enhanced
OT  - Coronary artery disease
OT  - Coronary magnetic resonance angiography
OT  - Late gadolinium enhancement
OT  - Stress-rest perfusion imaging
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocol was approved by 
      the Ethics Committee of Beijing Anzhen Hospital. Written informed consent was 
      obtained from the participants for publication of their individual details and 
      images in this manuscript. The consent forms are held at the authors' institution 
      and are available for review by the Editor-in-Chief. CONSENT FOR PUBLICATION: All 
      the subjects provided written informed consent for the publication of 
      accompanying images in this manuscript. The consent forms are held in the 
      authors' institution and are available for review by the Editor-in-Chief. 
      COMPETING INTERESTS: The authors declare that they have no competing interests. 
      PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional 
      claims in published maps and institutional affiliations.
EDAT- 2018/05/01 06:00
MHDA- 2019/03/15 06:00
PMCR- 2018/04/30
CRDT- 2018/05/01 06:00
PHST- 2017/06/23 00:00 [received]
PHST- 2018/04/06 00:00 [accepted]
PHST- 2018/05/01 06:00 [entrez]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/04/30 00:00 [pmc-release]
AID - S1097-6647(23)00566-5 [pii]
AID - 450 [pii]
AID - 10.1186/s12968-018-0450-2 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2018 Apr 30;20(1):29. doi: 10.1186/s12968-018-0450-2.