PMID- 29706843
OWN - NLM
STAT- MEDLINE
DCOM- 20190710
LR  - 20190710
IS  - 1555-4317 (Electronic)
IS  - 1555-4309 (Print)
IS  - 1555-4309 (Linking)
VI  - 2018
DP  - 2018
TI  - NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using 
      Heptamethine Carbocyanine Dye.
PG  - 4979746
LID - 10.1155/2018/4979746 [doi]
LID - 4979746
AB  - Combining near-infrared fluorescence (NIRF) and nuclear imaging techniques 
      provides a novel approach for hepatocellular carcinoma (HCC) diagnosis. Here, we 
      report the synthesis and characteristics of a dual-modality NIRF optical/positron 
      emission tomography (PET) imaging probe using heptamethine carbocyanine dye and 
      verify its feasibility in both nude mice and rabbits with orthotopic xenograft 
      liver cancer. This dye, MHI-148, is an effective cancer-specific NIRF imaging 
      agent and shows preferential uptake and retention in liver cancer. The 
      corresponding NIRF imaging intensity reaches 10(9)/cm(2) tumor area at 24 h after 
      injection in mice with HCC subcutaneous tumors. The dye can be further conjugated 
      with radionuclide (68)Ga ((68)Ga-MHI-148) for PET tracing. We applied the 
      dual-modality methodology toward the detection of HCC in both patient-derived 
      orthotopic xenograft (PDX) models and rabbit orthotopic transplantation models. 
      NIRF/PET images showed clear tumor delineation after probe injection (MHI-148 and 
      (68)Ga-MHI-148). The tumor-to-muscle (T/M) standardized uptake value (SUV) ratios 
      were obtained from PET at 1 h after injection of (68)Ga-MHI-148, which was 
      helpful for effectively capturing small tumors in mice (0.5 cm x 0.3 cm) and 
      rabbits (1.2 cm x 1.8 cm). This cancer-targeting NIRF/PET dual-modality imaging 
      probe provides a proof of principle for noninvasive detection of deep-tissue 
      tumors in mouse and rabbit and is a promising technique for more accurate and 
      early detection of HCC.
FAU - Zhang, Caiqin
AU  - Zhang C
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Zhao, Yong
AU  - Zhao Y
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Zhao, Ningning
AU  - Zhao N
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Tan, Dengxu
AU  - Tan D
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Zhang, He
AU  - Zhang H
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Chen, Xue
AU  - Chen X
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Zhang, Hai
AU  - Zhang H
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - An, Jiaze
AU  - An J
AD  - Department of Hepatobiliary and Pancreaticosplenic Surgery, Xijing Hospital, The 
      Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
FAU - Shi, Changhong
AU  - Shi C
AUID- ORCID: 0000-0001-7490-3593
AD  - Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 
      710032, China.
FAU - Li, Mengbin
AU  - Li M
AUID- ORCID: 0000-0003-4946-4618
AD  - State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, 
      The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180308
PL  - England
TA  - Contrast Media Mol Imaging
JT  - Contrast media & molecular imaging
JID - 101286760
RN  - 0 (Carbocyanines)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Gallium Radioisotopes)
SB  - IM
MH  - Animals
MH  - *Carbocyanines/pharmacokinetics
MH  - Carcinoma, Hepatocellular/*diagnosis
MH  - Cell Line, Tumor
MH  - Fluorescent Dyes
MH  - *Gallium Radioisotopes
MH  - Heterografts
MH  - Humans
MH  - Liver Neoplasms/*diagnosis
MH  - Mice
MH  - Multimodal Imaging/*methods
MH  - Optical Imaging/methods
MH  - Positron-Emission Tomography/methods
MH  - Rabbits
PMC - PMC5863326
EDAT- 2018/05/01 06:00
MHDA- 2019/07/11 06:00
PMCR- 2018/03/08
CRDT- 2018/05/01 06:00
PHST- 2017/09/30 00:00 [received]
PHST- 2018/01/13 00:00 [revised]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/05/01 06:00 [entrez]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2019/07/11 06:00 [medline]
PHST- 2018/03/08 00:00 [pmc-release]
AID - 10.1155/2018/4979746 [doi]
PST - epublish
SO  - Contrast Media Mol Imaging. 2018 Mar 8;2018:4979746. doi: 10.1155/2018/4979746. 
      eCollection 2018.