PMID- 29707341
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 10
IP  - 3
DP  - 2018 Mar
TI  - Short-term one-lung ventilation does not influence local inflammatory cytokine 
      response after lung resection.
PG  - 1864-1874
LID - 10.21037/jtd.2018.03.50 [doi]
AB  - BACKGROUND: One-lung ventilation (OLV) is a ventilation procedure used for 
      pulmonary resection which may results in lung injury. The aim of this study was 
      to evaluate the local inflammatory cytokine response from the dependent lung 
      after OLV and its correlation to VT. The secondary aim was to evaluate the 
      clinical outcome of each patient. METHODS: Twenty-eight consecutive patients were 
      enrolled. Ventilation was delivered in volume-controlled mode with a VT based on 
      predicted body weight (PBW). 5 cmH(2)O positive end-expiratory pressure (PEEP) 
      and FiO(2) 0.5 were applied. Bronchoalveolar lavage (BAL) was performed in the 
      dependent lung before and after OLV. The levels of pro-inflammatory interleukins 
      (IL-1alpha, IL-1beta, IL-6, IL-8), tumor necrosis factor alpha (TNFalpha), vascular 
      endothelial growth factor (VEGF), endothelial growth factor (EGF), monocyte 
      chemoattractant protein-1 (MCP-1) and anti-inflammatory cytokines, such as 
      interleukins (IL-2, IL-4, IL-10) and interferon (IFN-gamma), were evaluated. Subgroup 
      analysis: to analyze the VT setting during OLV, all patients were ventilated 
      within a range of 5-10 mL/kg. Thirteen patients, classified as a conventional 
      ventilation (CV) subgroup, received 8-10 mL/kg, while 15 patients, classified as 
      a protective ventilation (PV) subgroup, received 5-7 mL/kg. RESULTS: Cytokine BAL 
      levels after surgery showed no significant increase after OLV, and no significant 
      differences were recorded between the two subgroups. The mean duration of OLV was 
      64.44+/-21.68 minutes. No postoperative respiratory complications were recorded. 
      The mean length of stay was for 4.00+/-1.41 days in the PV subgroup and 4.45+/-2.07 
      days in the CV group; no statistically significant differences were recorded 
      between the two subgroups (P=0.511). CONCLUSIONS: Localized inflammatory cytokine 
      response after OLV was not influenced by the use of different VT. Potentially, 
      the application of PEEP in both ventilation strategies and the short duration of 
      OLV could prevent postoperative complications.
FAU - Fiorelli, Silvia
AU  - Fiorelli S
AD  - Department of Anesthesiology and Intensive Care, Sapienza University of Rome, 
      Italy.
FAU - Defraia, Veronica
AU  - Defraia V
AD  - Department of Anesthesiology and Intensive Care, Sapienza University of Rome, 
      Italy.
FAU - Cipolla, Fabiola
AU  - Cipolla F
AD  - The Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), 
      Sapienza University of Rome, Italy.
FAU - Menna, Cecilia
AU  - Menna C
AD  - Department of Thoracic Surgery; Sapienza University of Rome, Italy.
FAU - Ibrahim, Mohsen
AU  - Ibrahim M
AD  - Department of Thoracic Surgery; Sapienza University of Rome, Italy.
FAU - Andreetti, Claudio
AU  - Andreetti C
AD  - Department of Thoracic Surgery; Sapienza University of Rome, Italy.
FAU - Simmaco, Maurizio
AU  - Simmaco M
AD  - The Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), 
      Sapienza University of Rome, Italy.
FAU - Rocco, Monica
AU  - Rocco M
AD  - Department of Anesthesiology and Intensive Care, Sapienza University of Rome, 
      Italy.
FAU - Rendina, Erino Angelo
AU  - Rendina EA
AD  - Department of Thoracic Surgery; Sapienza University of Rome, Italy.
FAU - Borro, Marina
AU  - Borro M
AD  - The Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), 
      Sapienza University of Rome, Italy.
FAU - Massullo, Domenico
AU  - Massullo D
AD  - Department of Anesthesiology and Intensive Care, Sapienza University of Rome, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5906264
OTO - NOTNLM
OT  - One-lung ventilation (OLV)
OT  - cytokines
OT  - inflammation
OT  - thoracic surgery
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2018/05/01 06:00
MHDA- 2018/05/01 06:01
PMCR- 2018/03/01
CRDT- 2018/05/01 06:00
PHST- 2018/05/01 06:00 [entrez]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2018/05/01 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - jtd-10-03-1864 [pii]
AID - 10.21037/jtd.2018.03.50 [doi]
PST - ppublish
SO  - J Thorac Dis. 2018 Mar;10(3):1864-1874. doi: 10.21037/jtd.2018.03.50.