PMID- 29707799
OWN - NLM
STAT- MEDLINE
DCOM- 20190213
LR  - 20190215
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 58
IP  - 8
DP  - 2018 Aug
TI  - Granulocyte antibodies in male blood donors: can they trigger transfusion-related 
      acute lung injury?
PG  - 1894-1901
LID - 10.1111/trf.14630 [doi]
AB  - BACKGROUND: White blood cell-associated antibodies can lead to 
      transfusion-related acute lung injury (TRALI). Female donors with a history of 
      pregnancies have been identified as a main cause for these antibodies. Male or 
      female donors without a history of pregnancy are considered as safe donors. STUDY 
      DESIGN AND METHODS: Following the identification of two TRALI cases associated 
      with blood products from male donors, we investigated the frequency of 
      granulocyte-specific and human leukocyte antigen (HLA) antibodies in the entire 
      blood donor population using a high throughput automated flow-cytometry-based 
      granulocyte immunofluorescence test (Flow-GIFT). We investigated sera from 14,343 
      whole blood donors (female, n = 6974, 48.7%; male, n = 7369, 51.3%) using 
      automated Flow-GIFT. Of the female blood donors, 60.4% had a history of 
      pregnancy. Positive sera were retested by the standard granulocyte 
      immunofluorescence test and granulocyte agglutination test. For the detection of 
      HLA Class I and II immunoglobulin G antibodies, we used a commercial screening 
      enzyme-linked immunosorbent assay. RESULTS: We detected in 924 (21.9%) of the 
      4212 females with a history of pregnancy antibodies against granulocyte antigens 
      (n = 62, 1.5%), HLA Class I and/or II antigens (n = 864, 20.5%). Notably, in 3.5% 
      (n = 96) of 2762 females without a history of pregnancy and in 2.1% (n = 154) of 
      7369 males antibodies against granulocyte antigens (n = 13, 0.47% and n = 45, 
      0.6%), HLA Class I and/or II (n = 83, 3% and n = 109, 1.4%, respectively), were 
      also detected. CONCLUSION: Human neutrophil antigen antibodies are rare in male 
      and females without a history of pregnancy compared to females with a history of 
      pregnancy, but their relevance is not negligible.
CI  - (c) 2018 AABB.
FAU - Nguyen, Xuan-Duc
AU  - Nguyen XD
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
FAU - Schulze, Torsten J
AU  - Schulze TJ
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
AD  - German Red Cross Blood Service NSTOB, Institute Springe, Springe, Germany.
FAU - Bugert, Peter
AU  - Bugert P
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
FAU - Lauber-Hartl, Stephanie
AU  - Lauber-Hartl S
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
FAU - Schulz-Linkholt, Monika
AU  - Schulz-Linkholt M
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
FAU - Gonzalez-Schulze, Karen
AU  - Gonzalez-Schulze K
AD  - Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, 
      Heidelberg University, German Red Cross Blood Service Baden-Wurttemberg-Hessen, 
      Mannheim, Germany.
FAU - Reil, Angelika
AU  - Reil A
AD  - German Red Cross Blood Service West, Hagen, Germany.
FAU - Dengler, Thomas
AU  - Dengler T
AD  - Institute of Transfusion Medicine and Immunohematology, Baden-Baden, German Red 
      Cross Blood Service Baden-Wurttemberg-Hessen, Baden-Baden, Germany.
FAU - Panzer, Simon
AU  - Panzer S
AD  - Department of Blood Group Serology and Transfusion Medicine, Medical University 
      Vienna, Vienna, Austria.
FAU - Seifried, Erhard
AU  - Seifried E
AD  - Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood 
      Service Baden-Wurttemberg-Hessen, Goethe University Hospital, Frankfurt am Main, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20180429
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoantibodies/*blood
MH  - *Blood Donors
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry/methods
MH  - Granulocytes/*immunology
MH  - HLA Antigens/blood
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mass Screening
MH  - Neutrophils
MH  - Pregnancy
MH  - Transfusion-Related Acute Lung Injury/*etiology
EDAT- 2018/05/01 06:00
MHDA- 2019/02/14 06:00
CRDT- 2018/05/01 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2018/02/23 00:00 [revised]
PHST- 2018/03/04 00:00 [accepted]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
PHST- 2018/05/01 06:00 [entrez]
AID - 10.1111/trf.14630 [doi]
PST - ppublish
SO  - Transfusion. 2018 Aug;58(8):1894-1901. doi: 10.1111/trf.14630. Epub 2018 Apr 29.