PMID- 29708498
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20190802
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 10
IP  - 4
DP  - 2018 Apr 29
TI  - Transcriptional profiling identifies strain-specific effects of caloric 
      restriction and opposite responses in human and mouse white adipose tissue.
PG  - 701-746
LID - 10.18632/aging.101424 [doi]
AB  - Caloric restriction (CR) has been extensively studied in rodents as an 
      intervention to improve lifespan and healthspan. However, effects of CR can be 
      strain- and species-specific. This study used publically available microarray 
      data to analyze expression responses to CR in males from 7 mouse strains 
      (C57BL/6J, BALB/c, C3H, 129, CBA, DBA, B6C3F1) and 4 tissues (epididymal white 
      adipose tissue (eWAT), muscle, heart, cortex). In each tissue, the largest number 
      of strain-specific CR responses was identified with respect to the C57BL/6 
      strain. In heart and cortex, CR responses in C57BL/6 mice were negatively 
      correlated with responses in other strains. Strain-specific CR responses involved 
      genes associated with olfactory receptors (Olfr1184, Olfr910) and insulin/IGF-1 
      signaling (Igf1, Irs2). In each strain, CR responses in eWAT were negatively 
      correlated with those in human subcutaneous WAT (scWAT). In human scWAT, CR 
      increased expression of genes associated with stem cell maintenance and 
      vascularization. However, orthologous genes linked to these processes were 
      down-regulated in mouse. These results identify strain-specific CR responses 
      limiting generalization across mouse strains. Differential CR responses in mouse 
      versus human WAT may be due to differences in the depots examined and/or the 
      presence of "thrifty genes" in humans that resist adipose breakdown despite 
      caloric deficit.
FAU - Swindell, William R
AU  - Swindell WR
AD  - Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
FAU - List, Edward O
AU  - List EO
AD  - Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
AD  - Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
AD  - The Diabetes Institute, Ohio University, Athens, OH 45701, USA.
FAU - Berryman, Darlene E
AU  - Berryman DE
AD  - Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
AD  - Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
AD  - The Diabetes Institute, Ohio University, Athens, OH 45701, USA.
FAU - Kopchick, John J
AU  - Kopchick JJ
AD  - Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
AD  - Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
AD  - The Diabetes Institute, Ohio University, Athens, OH 45701, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Gene Expression Profiling
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Inbred DBA
MH  - Models, Animal
MH  - *Species Specificity
MH  - *Transcriptome
PMC - PMC5940131
OTO - NOTNLM
OT  - adipose
OT  - aging
OT  - dietary restriction
OT  - insulin
OT  - insulin-like growth factor
OT  - longevity
OT  - microarray
OT  - olfactory receptor
COIS- CONFLICTS OF INTEREST: The authors declare that the research was conducted in the 
      absence of any commercial or financial relationships that could be construed as a 
      potential conflict of interest.
EDAT- 2018/05/01 06:00
MHDA- 2019/08/03 06:00
PMCR- 2018/04/01
CRDT- 2018/05/01 06:00
PHST- 2018/02/27 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PHST- 2018/05/01 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 101424 [pii]
AID - 10.18632/aging.101424 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2018 Apr 29;10(4):701-746. doi: 10.18632/aging.101424.