PMID- 29708579
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1309-5730 (Electronic)
IS  - 1018-5615 (Linking)
VI  - 34
IP  - 3
DP  - 2018
TI  - Evaluation of the Prognostic Importance of c-Myc and Bcl-2 Expressions and the 
      Presence of Epstein-Barr Virus in Classical Hodgkin Lymphoma.
PG  - 199-206
LID - 10.5146/tjpath.2018.01430 [doi]
AB  - OBJECTIVE: Although classical Hodgkin lymphoma (cHL) has a relatively good 
      prognosis, it also entails different treatment responses and involves patients 
      who have different clinical courses. Our aim was to investigate c-Myc, Bcl-2 and 
      EBV biomarkers in cHL and their relationship with the IPS score. MATERIAL AND 
      METHOD: c-Myc and Bcl-2 immunohistochemical staining with EBER in situ 
      hybridization (EBER-ISH) was applied to the paraffin sections of 94 cases 
      diagnosed as cHL. These cases were classified into two groups as low and high 
      clinical symptoms according to the International Prognostic Scores (IPS). 
      RESULTS: Positive results were obtained in 83 (88.3%) cases with c-Myc and 39 
      (43.5%) cases with Bcl-2 while EBER-ISH was found positive in 42 (44.7%) cases. 
      No difference was found between the groups of low/high IP scores with respect to 
      the positive or negative results of EBER-ISH, Bcl-2 and c-Myc. When Bcl-2 and 
      c-Myc positive cases were grouped together and compared to the IP scores of the 
      remaining cHL cases, again no difference was seen. Extranodal involvement and 
      bone marrow involvement was observed in 25 (26.5%) and 9 (9.5%) cases, 
      respectively. Similarly, no statistically significant differences was found 
      between these groups according to their positivity with EBER-ISH, Bcl-2 and 
      c-Myc. CONCLUSION: We could not find any relationship between Bcl-2, c-Myc and 
      EBER-ISH positivity and the low/high IPS groups in cHL. New studies with larger 
      series are needed in which more precise cut-off values are used and clinically 
      and biologically heterogeneous groups of cHL patients are determined more 
      clearly.
FAU - Kilicarslan, Aydan
AU  - Kilicarslan A
AD  - Department of Pathology, Ankara Yildirim Beyazit University, School of Medicine, 
      ANKARA, TURKEY.
FAU - Ozturk, Vedia
AU  - Ozturk V
FAU - Yikilmaz, Aysun Senturk
AU  - Yikilmaz AS
FAU - Dogan, Mehmet
AU  - Dogan M
FAU - Akyol, Mesut
AU  - Akyol M
LA  - eng
PT  - Journal Article
TT  - Evaluation of the Prognostic Importance of c-Myc and Bcl-2 Expressions and the 
      Presence of Epstein-Barr Virus in Classical Hodgkin Lymphoma.
PL  - Turkey
TA  - Turk Patoloji Derg
JT  - Turk patoloji dergisi
JID - 9440471
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Epstein-Barr Virus Infections/*epidemiology
MH  - Female
MH  - Hodgkin Disease/*classification/mortality/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/analysis/*biosynthesis
MH  - Proto-Oncogene Proteins c-myc/analysis/*biosynthesis
MH  - Risk Factors
MH  - Young Adult
EDAT- 2018/05/01 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/05/01 06:00
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/05/01 06:00 [entrez]
AID - 10.5146/tjpath.2018.01430 [doi]
PST - ppublish
SO  - Turk Patoloji Derg. 2018;34(3):199-206. doi: 10.5146/tjpath.2018.01430.