PMID- 29710809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240318
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 7
IP  - 5
DP  - 2018 Apr 28
TI  - Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives 
      for Neuroprotection in Alzheimer's Disease.
LID - 10.3390/antiox7050063 [doi]
LID - 63
AB  - The ketogenic diet, originally developed for the treatment of epilepsy in 
      non-responder children, is spreading to be used in the treatment of many 
      diseases, including Alzheimer’s disease. The main activity of the ketogenic 
      diet has been related to improved mitochondrial function and decreased oxidative 
      stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce 
      the production of reactive oxygen species (ROS), improving mitochondrial 
      respiration: it stimulates the cellular endogenous antioxidant system with the 
      activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it 
      modulates the ratio between the oxidized and reduced forms of nicotinamide 
      adenine dinucleotide (NAD(+)/NADH) and it increases the efficiency of electron 
      transport chain through the expression of uncoupling proteins. Furthermore, the 
      ketogenic diet performs anti-inflammatory activity by inhibiting nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NF-kB) activation and 
      nucleotide-binding domain, leucine-rich-containing family, pyrin 
      domain-containing-3 (NLRP3) inflammasome as well as inhibiting histone 
      deacetylases (HDACs), improving memory encoding. The underlying mechanisms and 
      the perspectives for the treatment of Alzheimer’s disease are discussed.
FAU - Pinto, Alessandro
AU  - Pinto A
AUID- ORCID: 0000-0002-4864-2294
AD  - Department of Experimental Medicine, Sapienza University of Rome, 00161 Roma, 
      Italy. alessandro.pinto@uniroma1.it.
FAU - Bonucci, Alessio
AU  - Bonucci A
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, 04100 Latina, Italy. bonucci.alessio@libero.it.
FAU - Maggi, Elisa
AU  - Maggi E
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, 04100 Latina, Italy. elisa.maggi@biologo.onb.it.
FAU - Corsi, Mariangela
AU  - Corsi M
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, 04100 Latina, Italy. mariangela.corsi@uniroma1.it.
FAU - Businaro, Rita
AU  - Businaro R
AUID- ORCID: 0000-0002-7890-8524
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, 04100 Latina, Italy. rita.businaro@uniroma1.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180428
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC5981249
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Ketogenic diet
OT  - inflammation
OT  - neuroprotection
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/02 06:00
MHDA- 2018/05/02 06:01
PMCR- 2018/04/28
CRDT- 2018/05/02 06:00
PHST- 2018/03/30 00:00 [received]
PHST- 2018/04/23 00:00 [revised]
PHST- 2018/04/25 00:00 [accepted]
PHST- 2018/05/02 06:00 [entrez]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/05/02 06:01 [medline]
PHST- 2018/04/28 00:00 [pmc-release]
AID - antiox7050063 [pii]
AID - antioxidants-07-00063 [pii]
AID - 10.3390/antiox7050063 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2018 Apr 28;7(5):63. doi: 10.3390/antiox7050063.