PMID- 29712742
OWN - NLM
STAT- MEDLINE
DCOM- 20190228
LR  - 20231112
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 71
IP  - 6
DP  - 2018 Jun
TI  - Persistent Organochlorine Pollutants in Plasma, Blood Pressure, and Hypertension 
      in a Longitudinal Study.
PG  - 1258-1268
LID - 10.1161/HYPERTENSIONAHA.117.10691 [doi]
AB  - Persistent organochlorine pollutants (POPs) have shown to be involved in the 
      atherosclerotic process and to cause endothelial cell dysfunction. To assess 
      longitudinally whether plasma concentrations of different POPs were associated 
      with blood pressure and risk of hypertension in middle-aged women and men. Study 
      subjects were 850 participants in the VIP (Vasterbotten Intervention Programme) 
      with 2 blood samples and blood pressure measurements, 10 years apart, during 1990 
      to 2003 (baseline) and during 2000 to 2013 (follow-up). Dioxin-like and 
      nondioxin-like polychlorinated biphenyls (DL-PCBs, NDL-PCBs) and 
      p,p'-dichlorodiphenyldichloroethylene (DDE) were measured. Associations were 
      assessed using generalized estimating equations. At baseline sampling 49% and at 
      follow-up 64% had hypertension. DL-PCBs and DDE, but not NDL-PCBs or 
      hexachlorobenzene, were associated with hypertension. Only the association for 
      DL-PCBs remained statistically significant after lipid-standardization and 
      adjustment for body mass index and total serum lipids. The multivariable-adjusted 
      odds ratio of hypertension based on repeated measurements were 1.52 (95% 
      confidence interval, 1.08-2.13) for DL-PCBs (third versus first tertile of 
      lipid-standardized POPs). In stratified adjusted analyses, odds ratio for those 
      born after 1950 increased to 3.99 (95% confidence interval, 2.15-7.43), whereas 
      no association was observed among those born earlier. Based on repeated 
      measurements, the accumulated exposure to DL-PCBs and DDE, although less clear 
      for the latter, may disrupt the normal blood pressure levels and increase the 
      odds of hypertension. Moreover, individuals experiencing early-life POP exposure 
      may be at elevated risk of vascular POP effects.
CI  - (c) 2018 The Authors.
FAU - Donat-Vargas, Carolina
AU  - Donat-Vargas C
AD  - From the Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm, Sweden (C.D.-V., A.A.).
FAU - Akesson, Agneta
AU  - Akesson A
AD  - From the Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm, Sweden (C.D.-V., A.A.) Agneta.Akesson@ki.se.
FAU - Tornevi, Andreas
AU  - Tornevi A
AD  - Department of Public Health and Clinical Medicine, Occupational and Environmental 
      Medicine (A.T., J.S., I.A.B.).
FAU - Wennberg, Maria
AU  - Wennberg M
AD  - and Nutritional Research (M.W.).
FAU - Sommar, Johan
AU  - Sommar J
AD  - Department of Public Health and Clinical Medicine, Occupational and Environmental 
      Medicine (A.T., J.S., I.A.B.).
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Umea University, Sweden; and Department for Health Security, Environmental Health 
      Unit, National Institute for Health and Welfare, Kuopio, Finland (H.K., P.R.).
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - Umea University, Sweden; and Department for Health Security, Environmental Health 
      Unit, National Institute for Health and Welfare, Kuopio, Finland (H.K., P.R.).
FAU - Bergdahl, Ingvar A
AU  - Bergdahl IA
AD  - Department of Public Health and Clinical Medicine, Occupational and Environmental 
      Medicine (A.T., J.S., I.A.B.).
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180430
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Air Pollutants)
RN  - 0 (Biomarkers)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Air Pollutants/*adverse effects
MH  - Biomarkers/blood
MH  - Blood Pressure/*physiology
MH  - Body Mass Index
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*adverse effects/blood
MH  - Hypertension/*blood/epidemiology/physiopathology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Risk Assessment/*methods
MH  - Sweden/epidemiology
PMC - PMC5959216
OTO - NOTNLM
OT  - DDE
OT  - dioxin-like polychlorinated biphenyls
OT  - early-life exposures
OT  - exposure via diet
OT  - hypertension
EDAT- 2018/05/02 06:00
MHDA- 2019/03/01 06:00
PMCR- 2018/05/18
CRDT- 2018/05/02 06:00
PHST- 2017/12/04 00:00 [received]
PHST- 2017/12/22 00:00 [revised]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2019/03/01 06:00 [medline]
PHST- 2018/05/02 06:00 [entrez]
PHST- 2018/05/18 00:00 [pmc-release]
AID - HYPERTENSIONAHA.117.10691 [pii]
AID - 10.1161/HYPERTENSIONAHA.117.10691 [doi]
PST - ppublish
SO  - Hypertension. 2018 Jun;71(6):1258-1268. doi: 10.1161/HYPERTENSIONAHA.117.10691. 
      Epub 2018 Apr 30.