PMID- 29715537
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181202
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 349
DP  - 2018 Sep 3
TI  - Resveratrol prevents cognitive deficits induced by chronic unpredictable mild 
      stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in 
      hippocampus in vivo and in vitro.
PG  - 1-7
LID - S0166-4328(18)30412-1 [pii]
LID - 10.1016/j.bbr.2018.04.050 [doi]
AB  - Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, 
      such as depression, anxiety and cognitive impairment. Resveratrol is a natural 
      polyphenol existed in polygonum cuspidatum and has been demonstrated to be a 
      potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol 
      treatment ameliorated CUMS-induced depressive-like behavior and cognitive 
      deficits through upregulating cAMP response element-binding protein (CREB) and 
      brain derived neurotrophic factor (BDNF) expression. However, the upstream 
      signalling pathway mediating CREB/BDNF expression and then exerting a protective 
      role on cognitive function remains unclear. The present study aims to investigate 
      the possible mechanism of resveratrol on CUMS-induced cognitive deficits. Male 
      Sprague Dawley rats were adminstrated resveratrol (40 and 80 mg/kg) every day for 
      4 consecutive weeks before exposure to CUMS procedure. Morris Water Maze test was 
      used to appraise spatial learing and memory of rats. Sirt1/miR-134 signalling 
      pathway and CREB/BDNF expression in hippocampus of rats were measured. We also 
      explored Sirt1/miR-134 signalling pathway and CREB/BDNF expression in primary 
      cultured hippocampus neurons with resveratrol (25, 50 and 100 mumol/L) treatment. 
      We found that resveratrol treatment prevented spatial learing and memory 
      impairment induced by CUMS. Meanwhile the potential mechanism of resveratrol was 
      associated with increased levels of Sirt1, CREB phosphorylation (p-CREB), CREB, 
      BDNF and decreased levels of miR-134 in vivo and in vitro. In conclusion, our 
      study showed that the neuroprotective effect of resveratrol on CUMS-induced 
      cognitive impairment may rely on activating Sirt1/miR-134 pathway and then 
      upregulating its downstream CREB/BDNF expression in hippocampus.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Shen, Jun
AU  - Shen J
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China.
FAU - Xu, Linling
AU  - Xu L
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China.
FAU - Qu, Chujie
AU  - Qu C
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China.
FAU - Sun, Huimin
AU  - Sun H
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China.
FAU - Zhang, Junjian
AU  - Zhang J
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China. Electronic address: wdsjkx@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180430
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (MIRN134 microRNA, rat)
RN  - 0 (MicroRNAs)
RN  - 0 (Nootropic Agents)
RN  - 0 (Stilbenes)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognitive Dysfunction/*drug therapy/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - MicroRNAs/metabolism
MH  - Nootropic Agents/*pharmacology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Resveratrol
MH  - Sirtuin 1/metabolism
MH  - Spatial Memory/drug effects/physiology
MH  - Stilbenes/*pharmacology
MH  - Stress, Psychological/drug therapy/metabolism
MH  - Uncertainty
OTO - NOTNLM
OT  - Chronic unpredictable mild stress
OT  - Cognitive impairment
OT  - Resveratrol
OT  - Sirt1
OT  - miR-134
EDAT- 2018/05/02 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/05/02 06:00
PHST- 2018/03/19 00:00 [received]
PHST- 2018/04/27 00:00 [revised]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/05/02 06:00 [entrez]
AID - S0166-4328(18)30412-1 [pii]
AID - 10.1016/j.bbr.2018.04.050 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 Sep 3;349:1-7. doi: 10.1016/j.bbr.2018.04.050. Epub 2018 
      Apr 30.