PMID- 29715601
OWN - NLM
STAT- MEDLINE
DCOM- 20190906
LR  - 20190906
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 165
DP  - 2018 Aug
TI  - Longitudinal changes in persistent organic pollutants (POPs) from 2001 to 2009 in 
      a sample of elderly Swedish men and women.
PG  - 193-200
LID - S0013-9351(18)30206-8 [pii]
LID - 10.1016/j.envres.2018.04.009 [doi]
AB  - BACKGROUND: Prospective cohort studies evaluating the temporal trends of 
      background-level persistent organic pollutants (POPs) and their potential 
      negative health effects in humans are needed. OBJECTIVE: The objectives of this 
      study are to examine the five year longitudinal trend in chlorinated and 
      brominated (Cl/Br) POP concentrations in a sample of elderly individuals and to 
      investigate the relationship between gender, changes in body weight, plasma lipid 
      levels and POP concentrations. METHODS: In the population-based Prospective 
      Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, plasma samples 
      were collected from the same individuals over a 5 year period. Originally 992 
      subjects (all aged 70) were sampled between 2001 and 2004 and 814 returning 
      subjects (all aged 75) were sampled again from 2006 to 2009. Plasma 
      concentrations of 16 polychlorinated biphenyls (PCBs), 5 organochlorine 
      pesticides (OCPs), octachlorinated dibenzo-p-dioxin (OCDD), and one 
      polybrominated diphenylether (BDE 47) were determined using high-throughput 
      96-well plate solid phase extraction and gas chromatography-high resolution mass 
      spectrometry (GC-HRMS). RESULTS: During the 5-year follow-up, plasma 
      concentrations of all POPs significantly decreased (p < 0.00001). Median 
      reductions ranged from 4% (PCB105) to 45% (PCB 99), with most reductions being in 
      the 30-40% range. For most POPs, a larger decline was seen in men than in women. 
      The relationship between the weight change and change in POP concentrations was 
      generally negative, but a positive relationship between lipid levels and POP 
      concentrations when expressed as wet-weight was observed. In general, similar 
      changes in POP concentrations and their relationships to body weight were 
      observed regardless of using either wet-weight (pg/mL) or lipid-normalized (ng/g 
      lipid) concentrations. CONCLUSION: In this longitudinal cohort study, gender and 
      minor, but varying changes in body weight and lipid levels greatly influenced the 
      individual-based changes in POP concentrations. In general, our findings suggest 
      that men and women with larger decreases in body weight and greater increases in 
      lipid levels have the slowest decline in body burden of POPs. Based on the 
      results from this study, either wet-weight or lipid normalized concentrations can 
      be used to determine the percent change in POP concentrations and their 
      relationships to physiological changes and differences.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Stubleski, Jordan
AU  - Stubleski J
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, Sweden.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden; Department of Medical Sciences and Science for Life Laboratory, Molecular 
      Epidemiology Unit, Uppsala University, Uppsala, Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden.
FAU - Karrman, Anna
AU  - Karrman A
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden. Electronic address: anna.karrman@oru.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180430
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - O1B5KJ235I (dibenzo(1,4)dioxin)
SB  - IM
MH  - Aged
MH  - Dioxins/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Prospective Studies
MH  - Sweden
OTO - NOTNLM
OT  - Body weight
OT  - Longitudinal trend
OT  - PIVUS cohort
OT  - Persistent organic pollutants
OT  - Plasma lipids
EDAT- 2018/05/02 06:00
MHDA- 2019/09/07 06:00
CRDT- 2018/05/02 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/04/11 00:00 [accepted]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
PHST- 2018/05/02 06:00 [entrez]
AID - S0013-9351(18)30206-8 [pii]
AID - 10.1016/j.envres.2018.04.009 [doi]
PST - ppublish
SO  - Environ Res. 2018 Aug;165:193-200. doi: 10.1016/j.envres.2018.04.009. Epub 2018 
      Apr 30.