PMID- 29717802
OWN - NLM
STAT- MEDLINE
DCOM- 20190129
LR  - 20230524
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 17
IP  - 8
DP  - 2018 Nov
TI  - The effect of enriched environment across ages: A study of anhedonia and BDNF 
      gene induction.
PG  - e12485
LID - 10.1111/gbb.12485 [doi]
AB  - Enriched environment treatment (EET) is a potential intervention for depression 
      by inducing brain-derived neurotrophic factor (BDNF). However, its age dependency 
      remains unclear. We recently found that EET during early-life development (ED) 
      was effective in increasing exploratory activity and anti-despair behavior, 
      particularly in promoter IV-driven BDNF deficient mice (KIV), with the largest 
      BDNF protein induction in the hippocampus and frontal cortex. Here, we further 
      determined age dependency of EET effects on anhedonia and promoter-specific BDNF 
      transcription, by using the sucrose preference test and qRT-PCR. Wild-type (WT) 
      and KIV mice received 2 months of EET during ED, young-adulthood and 
      old-adulthood (0-2, 2-4 and 12-14 months, respectively). All KIV groups showed 
      reduced sucrose preference, which EET equally reversed regardless of age. EET 
      increased hippocampal BDNF mRNA levels for all ages and genotypes, but increased 
      frontal cortex BDNF mRNA levels only in ED KIV and old WT mice. Transcription by 
      promoters I and IV was age-dependent in the hippocampus of WT mice: more 
      effective induction of exon IV or I during ED or old-adulthood, respectively. 
      Transcription by almost all 9 promoters was age-specific in the frontal cortex, 
      mostly observed in ED KIV mice. After discontinuance of EET, the EET effects on 
      anti-anhedonia and BDNF transcription in both regions persisted only in ED KIV 
      mice. These results suggested that EET was equally effective in reversing 
      anhedonia and inducing hippocampal BDNF transcription, but was more effective 
      during ED in inducing frontal cortex BDNF transcription and for lasting 
      anti-anhedonic and BDNF effects particularly in promoter IV-BDNF deficiency.
CI  - (c) 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics 
      Society.
FAU - Dong, B E
AU  - Dong BE
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 
      Memphis, Tennessee.
FAU - Xue, Y
AU  - Xue Y
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 
      Memphis, Tennessee.
FAU - Sakata, K
AU  - Sakata K
AUID- ORCID: 0000-0001-6509-216X
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 
      Memphis, Tennessee.
LA  - eng
GR  - R03 MH102445/MH/NIMH NIH HHS/United States
GR  - R21 MH105567/MH/NIMH NIH HHS/United States
GR  - R21 NS101703/NS/NINDS NIH HHS/United States
GR  - MH105567/MH/NIMH NIH HHS/United States
GR  - MH102445/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180531
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Anhedonia/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Depression/genetics
MH  - Depressive Disorder/genetics
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - Frontal Lobe/metabolism
MH  - Gene-Environment Interaction
MH  - Hippocampus/metabolism
MH  - Male
MH  - Mice
MH  - Promoter Regions, Genetic
PMC - PMC6214784
MID - NIHMS964045
OTO - NOTNLM
OT  - across ages
OT  - anhedonia
OT  - brain-derived neurotrophic factor (BDNF)
OT  - early life
OT  - enriched environment
OT  - gene expression
OT  - promoter IV
COIS- Conflict of Interest The authors declare no conflict of interest.
EDAT- 2018/05/03 06:00
MHDA- 2019/01/30 06:00
PMCR- 2019/11/01
CRDT- 2018/05/03 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/04/26 00:00 [revised]
PHST- 2018/04/26 00:00 [accepted]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2019/01/30 06:00 [medline]
PHST- 2018/05/03 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - 10.1111/gbb.12485 [doi]
PST - ppublish
SO  - Genes Brain Behav. 2018 Nov;17(8):e12485. doi: 10.1111/gbb.12485. Epub 2018 May 
      31.