PMID- 29719116
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20190409
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 39
IP  - 1
DP  - 2019 Jan
TI  - A brief primer on the mediational role of BDNF in the exercise-memory link.
PG  - 9-14
LID - 10.1111/cpf.12522 [doi]
AB  - One of the most amazing aspects of the human brain is its ability to learn 
      information and use it to change behaviour. A key neurotrophin that influences 
      memory function is brain-derived neurotrophic factor (BDNF). This review briefly 
      discusses the mechanistic role that BDNF may play in facilitating learning and 
      memory. We also describe the role of exercise on this relationship. As discussed 
      herein, BDNF may influence memory via BDNF-induced alterations in membrane 
      receptor expression and translocation, as well as activating several pathways 
      (PLC-y, PI3K, ERK) that act together to facilitate cellular effects that 
      influence synaptic plasticity. Exercise may help to facilitate BDNF expression 
      and its downstream cellular pathways from both direct and indirect mechanisms.
CI  - (c) 2018 Scandinavian Society of Clinical Physiology and Nuclear Medicine. 
      Published by John Wiley & Sons Ltd.
FAU - Loprinzi, Paul D
AU  - Loprinzi PD
AUID- ORCID: 0000-0001-7711-4741
AD  - Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, 
      Department of Health, Exercise Science and Recreation Management, The University 
      of Mississippi, University, MS, USA.
FAU - Frith, Emily
AU  - Frith E
AD  - Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, 
      Department of Health, Exercise Science and Recreation Management, The University 
      of Mississippi, University, MS, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180502
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/cytology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Exercise/*physiology/psychology
MH  - Humans
MH  - *Memory
MH  - *Neuronal Plasticity
MH  - Neurons/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - cellular
OT  - consolidation
OT  - learning
OT  - memory
OT  - physical activity
EDAT- 2018/05/03 06:00
MHDA- 2019/04/10 06:00
CRDT- 2018/05/03 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
PHST- 2018/05/03 06:00 [entrez]
AID - 10.1111/cpf.12522 [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2019 Jan;39(1):9-14. doi: 10.1111/cpf.12522. Epub 
      2018 May 2.