PMID- 29719139
OWN - NLM
STAT- MEDLINE
DCOM- 20190919
LR  - 20200225
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Print)
IS  - 2042-6976 (Linking)
VI  - 8
IP  - 9
DP  - 2018 Sep
TI  - Establishing the minimal clinically important difference for the Questionnaire of 
      Olfactory Disorders.
PG  - 1041-1046
LID - 10.1002/alr.22135 [doi]
AB  - BACKGROUND: Olfactory-specific quality of life (QOL) can be measured using the 
      Questionnaire of Olfactory Disorders Negative Statements (QOD-NS). Changes in the 
      QOD-NS after treatment can be difficult to interpret since there is no 
      standardized definition of clinically meaningful improvement. METHODS: Patients 
      with chronic rhinosinusitis (CRS) completed the QOD-NS. Four distribution-based 
      methods were used to calculate the minimal clinically important difference 
      (MCID): (1) one-half standard deviation (SD); (2) standard error of the mean 
      (SEM); (3) Cohen's effect size (d) of the smallest unit of change; and (4) 
      minimal detectable change (MDC). We also averaged all 4 of the scores together. 
      Finally, the likelihood of achieving a MCID after sinus surgery using these 
      methods, as well as average QOD-NS scores, was stratified by normal vs abnormal 
      baseline QOD-NS scores. RESULTS: Outcomes were examined on 128 patients. The mean 
      +/- SD improvement in QOD-NS score after surgery was 4.3 +/- 11.0 for the entire 
      cohort and 9.6 +/- 12.9 for those with abnormal baseline scores (p < 0.001). The 
      MCID values using the different techniques were: (1) SD = 6.5; (2) SEM = 3.1; (3) 
      d = 2.6; and (4) MDC = 8.6. The MCID score was 5.2 on average. For the total 
      cohort analysis, the likelihood of reporting a MCID ranged from 26% to 51%, and 
      49% to 70% for patients reporting preoperative abnormal olfaction. CONCLUSION: 
      Distribution-based MCID values of the QOD-NS range between 2.6 and 8.6 points, 
      with an average of 5.2. When stratified by preoperative QOD-NS scores the 
      majority of patients reporting abnormal preoperative QOD-NS scores achieved a 
      MCID.
CI  - (c) 2018 ARS-AAOA, LLC.
FAU - Mattos, Jose L
AU  - Mattos JL
AUID- ORCID: 0000-0001-8766-1626
AD  - Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and 
      Neck Surgery, University of Virginia, Charlottesville, VA.
AD  - Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and 
      Neck Surgery, Medical University of South Carolina, Charleston, SC.
FAU - Schlosser, Rodney J
AU  - Schlosser RJ
AD  - Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and 
      Neck Surgery, Medical University of South Carolina, Charleston, SC.
AD  - Department of Surgery, Ralph H. Johnson VA Medical Center, Charleston, SC.
FAU - Mace, Jess C
AU  - Mace JC
AD  - Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science 
      University, Portland, OR.
FAU - Smith, Timothy L
AU  - Smith TL
AUID- ORCID: 0000-0002-6424-7083
AD  - Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science 
      University, Portland, OR.
FAU - Soler, Zachary M
AU  - Soler ZM
AD  - Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and 
      Neck Surgery, Medical University of South Carolina, Charleston, SC.
LA  - eng
SI  - ClinicalTrials.gov/NCT02720653
GR  - R01 DC005805/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180502
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Endoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Olfaction Disorders/psychology/*surgery
MH  - Outcome Assessment, Health Care/*methods
MH  - Quality of Life
MH  - Rhinitis/psychology/surgery
MH  - Sinusitis/psychology/surgery
MH  - Smell
MH  - Surveys and Questionnaires/*standards
MH  - Young Adult
PMC - PMC6402812
MID - NIHMS957626
OTO - NOTNLM
OT  - minimal clinically important difference
OT  - olfaction
OT  - questionnaire of olfactory disorders
OT  - sinusitis
COIS- Potential Conflicts of Interest: Zachary M. Soler is supported by grants from 
      Entellus, Intersect, and Optinose, none of which are affiliated with this 
      manuscript. Dr. Soler is a consultant for Olympus, which is not affiliated with 
      this manuscript. Rodney J. Schlosser is supported by grants from OptiNose, 
      Entellus and IntersectENT, none of which are associated with this manuscript. Dr. 
      Schlosser is also a consultant for Olympus, Meda and Arrinex, which are not 
      affiliated with this study. There are no disclosures for Jose Mattos or Timothy 
      Smith.
EDAT- 2018/05/03 06:00
MHDA- 2019/09/20 06:00
PMCR- 2019/09/01
CRDT- 2018/05/03 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/03/13 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2019/09/20 06:00 [medline]
PHST- 2018/05/03 06:00 [entrez]
PHST- 2019/09/01 00:00 [pmc-release]
AID - 10.1002/alr.22135 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2018 Sep;8(9):1041-1046. doi: 10.1002/alr.22135. Epub 
      2018 May 2.