PMID- 29719493
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20181114
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 15
DP  - 2018
TI  - Effects of hydroxytyrosol dose on the redox status of exercised rats: the role of 
      hydroxytyrosol in exercise performance.
PG  - 20
LID - 10.1186/s12970-018-0221-3 [doi]
LID - 20
AB  - BACKGROUND: Hydroxytyrosol (HT) is a polyphenol found in olive oil that is known 
      for its antioxidant effects. Here, we aimed to describe the effects of a low and 
      high HT dose on the physical running capacity and redox state in both sedentary 
      and exercised rats. METHODS: Male Wistar rats were allocated into 6 groups: 
      sedentary (SED; n = 10); SED consuming 20 mg/kg/d HT (SED20; n = 7); SED 
      consuming 300 mg/kg/d HT (SED300; n = 7); exercised (EXE; n = 10); EXE consuming 
      20 mg/kg/d HT (EXE20; n = 10) and EXE consuming 300 mg/kg/d HT (EXE300; n = 10). 
      All the interventions lasted 10 weeks; the maximal running velocity was assessed 
      throughout the study, whereas daily physical work was monitored during each 
      training session. At the end of the study, the rats were sacrificed by bleeding. 
      Hemoglobin (HGB) and hematocrit (HCT) were measured in the terminal blood sample. 
      Moreover, plasma hydroperoxide (HPx) concentrations were quantified as markers of 
      lipid peroxidation. RESULTS: In sedentary rats, HT induced an antioxidant effect 
      in a dose-dependent manner without implications on running performance. However, 
      if combined with exercise, the 300 mg/kg/d HT dosage exhibited a pro-oxidant 
      effect in the EXE300 group compared with the EXE and EXE20 groups. The EXE20 rats 
      showed a reduction in daily physical work and a lower maximal velocity than the 
      EXE and EXE300 rats. The higher physical capacity exhibited by the EXE300 group 
      was achieved despite the EXE300 rats expressing lower HGB levels and a lower HCT 
      than the EXE20 rats. CONCLUSIONS: Our results suggest that a high HT dose induces 
      a systemic pro-oxidant effect and may prevent the loss of performance that was 
      observed with the low HT dose.
FAU - Al Fazazi, Saad
AU  - Al Fazazi S
AD  - "Jose Mataix" Institute of Nutrition and Food Technology, Biomedical Research 
      Centre, Department of Physiology, University of Granada, laboratory 116. Av. del 
      Conocimiento s/n, Armilla, 18100 Granada, Spain.
FAU - Casuso, Rafael A
AU  - Casuso RA
AD  - "Jose Mataix" Institute of Nutrition and Food Technology, Biomedical Research 
      Centre, Department of Physiology, University of Granada, laboratory 116. Av. del 
      Conocimiento s/n, Armilla, 18100 Granada, Spain.
FAU - Aragon-Vela, Jeronimo
AU  - Aragon-Vela J
AD  - "Jose Mataix" Institute of Nutrition and Food Technology, Biomedical Research 
      Centre, Department of Physiology, University of Granada, laboratory 116. Av. del 
      Conocimiento s/n, Armilla, 18100 Granada, Spain.
FAU - Casals, Cristina
AU  - Casals C
AD  - "Jose Mataix" Institute of Nutrition and Food Technology, Biomedical Research 
      Centre, Department of Physiology, University of Granada, laboratory 116. Av. del 
      Conocimiento s/n, Armilla, 18100 Granada, Spain.
FAU - Huertas, Jesus R
AU  - Huertas JR
AD  - "Jose Mataix" Institute of Nutrition and Food Technology, Biomedical Research 
      Centre, Department of Physiology, University of Granada, laboratory 116. Av. del 
      Conocimiento s/n, Armilla, 18100 Granada, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180427
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
RN  - 0 (Antioxidants)
RN  - 10597-60-1 (3,4-dihydroxyphenylethanol)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - ML9LGA7468 (Phenylethyl Alcohol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Hydrogen Peroxide/blood
MH  - Lipid Peroxidation
MH  - Male
MH  - Mitochondria/metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress/*drug effects
MH  - Phenylethyl Alcohol/*analogs & derivatives/pharmacology
MH  - *Physical Conditioning, Animal
MH  - Rats, Wistar
PMC - PMC5921979
OTO - NOTNLM
OT  - Antioxidants
OT  - Exercise
OT  - Hemoglobin
OT  - Oxidative stress
OT  - Polyphenols
OT  - ROS
COIS- The experiments were approved by the ethics committee of the University of 
      Granada (Granada, Spain; n degrees : 28/06/2016/116).Not applicable.The authors declare 
      that they have no competing interests.Springer Nature remains neutral with regard 
      to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/05/03 06:00
MHDA- 2018/07/19 06:00
PMCR- 2018/04/27
CRDT- 2018/05/03 06:00
PHST- 2017/03/21 00:00 [received]
PHST- 2018/04/12 00:00 [accepted]
PHST- 2018/05/03 06:00 [entrez]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2018/04/27 00:00 [pmc-release]
AID - 221 [pii]
AID - 10.1186/s12970-018-0221-3 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2018 Apr 27;15:20. doi: 10.1186/s12970-018-0221-3. 
      eCollection 2018.