PMID- 29719504
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 12
DP  - 2018
TI  - Descending Inputs to Spinal Circuits Facilitating and Inhibiting Human Wrist 
      Flexors.
PG  - 147
LID - 10.3389/fnhum.2018.00147 [doi]
LID - 147
AB  - Recently we reported in humans that electrical stimulation of the wrist extensor 
      muscle extensor carpi radialis (ECR) could facilitate or suppress the H reflex 
      elicited in flexor carpi radialis (FCR), for inter-stimulus intervals (ISIs) of 
      30 ms or 70 ms, respectively. The facilitation at 30 ms may be produced by both 
      flexor afferents and extensor Ib afferents acting on a spinal circuit; the origin 
      of the suppression at 70 ms is less certain. In this study, we investigated 
      possible descending inputs to these systems. We used magnetic stimulation of the 
      contralateral primary motor cortex, and click sound stimulation, to activate the 
      corticospinal and the reticulospinal tracts respectively, and measured the 
      effects on the H reflex conditioned by ECR stimulation. Corticospinal inputs 
      reduced both the 30 ms facilitation and 70 ms suppression, indicating 
      corticospinal inhibition of both circuits. By contrast, we failed to show any 
      effect of clicks, either on the H reflex or on its modulation by ECR stimulation. 
      This suggests that click-activated reticulospinal inputs to these circuits may be 
      weak or absent.
FAU - Aguiar, Stefane A
AU  - Aguiar SA
AD  - Institute of Neuroscience, Newcastle University Newcastle upon Tyne, United 
      Kingdom.
FAU - Baker, Stuart N
AU  - Baker SN
AD  - Institute of Neuroscience, Newcastle University Newcastle upon Tyne, United 
      Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20180417
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC5913321
OTO - NOTNLM
OT  - H-reflex
OT  - Ib afferents
OT  - click sound stimulation
OT  - corticospinal tract
OT  - reticulospinal tract
OT  - transcranial magnetic stimulation
EDAT- 2018/05/03 06:00
MHDA- 2018/05/03 06:01
PMCR- 2018/01/01
CRDT- 2018/05/03 06:00
PHST- 2018/02/09 00:00 [received]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/03 06:00 [entrez]
PHST- 2018/05/03 06:00 [pubmed]
PHST- 2018/05/03 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2018.00147 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2018 Apr 17;12:147. doi: 10.3389/fnhum.2018.00147. 
      eCollection 2018.