PMID- 29720767
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 0022-0116 (Print)
IS  - 1573-3564 (Electronic)
IS  - 0022-0116 (Linking)
VI  - 48
IP  - 2
DP  - 2018
TI  - Current Perspective on MDMA-Assisted Psychotherapy for Posttraumatic Stress 
      Disorder.
PG  - 99-108
LID - 10.1007/s10879-017-9379-2 [doi]
AB  - The present paper discusses the current literature with regard to 
      substance-assisted psychotherapy with Methylenedioxymethamphetamine (MDMA) for 
      posttraumatic stress disorder (PTSD). The aim of the paper is to give a 
      comprehensive overview of the development from MDMA's early application in 
      psychotherapy to its present and future role in the treatment of PTSD. It is 
      further attempted to increase the attention for MDMA's therapeutic potential by 
      providing a thorough depiction of the scientific evidence regarding its theorized 
      mechanism of action and potential harms of its application in the clinical 
      setting (e.g., misattribution of therapeutic gains to medication instead of 
      psychological changes). Empirical support for the use of MDMA-assisted 
      psychotherapy, including the randomized, double-blind, placebo-controlled trails 
      that have been conducted since 2008, is discussed. Thus far, an overall remission 
      rate of 66.2% and low rates of adverse effects have been found in the six phase 
      two trials conducted in clinical settings with 105 blinded subjects with chronic 
      PTSD. The results seem to support MDMA's safe and effective use as an adjunct to 
      psychotherapy. Even though preliminary studies may look promising, more studies 
      of its application in a psychotherapeutic context are needed in order to 
      establish MDMA as a potential adjunct to therapy.
FAU - Thal, Sascha B
AU  - Thal SB
AD  - Department of Clinical Psychology and Experimental Psychopathology, University of 
      Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, The Netherlands. ISNI: 0000 
      0004 0407 1981. GRID: grid.4830.f
FAU - Lommen, Miriam J J
AU  - Lommen MJJ
AD  - Department of Clinical Psychology and Experimental Psychopathology, University of 
      Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, The Netherlands. ISNI: 0000 
      0004 0407 1981. GRID: grid.4830.f
LA  - eng
PT  - Journal Article
DEP - 20180106
PL  - United States
TA  - J Contemp Psychother
JT  - Journal of contemporary psychotherapy
JID - 0171675
EIN - J Contemp Psychother. 2018;48(2):109. PMID: 31329660
PMC - PMC5917000
OTO - NOTNLM
OT  - MDMA
OT  - MDMA-assisted therapy
OT  - Overview
OT  - PTSD
OT  - Substance-assisted therapy
COIS- Compliance with Ethical StandardsSascha Thal reports being an intern at FINDER in 
      Berlin-a non-profit organization dedicated to conducting research about 
      harm-reduction and drug prevention, but declares there are no financial or other 
      gains involved and the overview has been written independently of the internship. 
      Miriam Lommen declares that she has no conflict of interest.This article does not 
      contain any studies with human participants or animals performed by any of the 
      authors.
EDAT- 2018/05/04 06:00
MHDA- 2018/05/04 06:01
PMCR- 2018/01/06
CRDT- 2018/05/04 06:00
PHST- 2018/05/04 06:00 [entrez]
PHST- 2018/05/04 06:00 [pubmed]
PHST- 2018/05/04 06:01 [medline]
PHST- 2018/01/06 00:00 [pmc-release]
AID - 9379 [pii]
AID - 10.1007/s10879-017-9379-2 [doi]
PST - ppublish
SO  - J Contemp Psychother. 2018;48(2):99-108. doi: 10.1007/s10879-017-9379-2. Epub 
      2018 Jan 6.