PMID- 29721512 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 2324-7096 (Print) IS - 2324-7096 (Electronic) IS - 2324-7096 (Linking) VI - 5 IP - 3 DP - 2017 Jul-Sep TI - Etanercept-Induced Hypoglycemia in a Patient With Psoriatic Arthritis and Diabetes. PG - 2324709617727760 LID - 10.1177/2324709617727760 [doi] LID - 2324709617727760 AB - Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis and inflammation involving the axial skeleton and/or peripheral joints. It is more likely to be associated with metabolic syndrome and diabetes when compared with other inflammatory arthritides. Tumor necrosis factor-alpha (TNF-alpha) is one of several cytokines often elevated in rheumatologic disorders including PsA and has also been found to be elevated in patients with obesity, metabolic syndrome, diabetes, and/or atherosclerotic disease. We describe the case of a patient with PsA as well as poorly controlled type 2 diabetes mellitus who experienced not only improvement in his psoriasis and arthritis with the anti-TNF-alpha agent etanercept but also recurrent hypoglycemia and significant improvement in hemoglobin A1c despite discontinuation of all conventional therapy for diabetes. FAU - Pfeifer, Emily C AU - Pfeifer EC AD - University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. FAU - Saxon, David R AU - Saxon DR AD - University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. AD - Denver Veterans Affairs Medical Center, Denver, CO, USA. FAU - Janson, Robert W AU - Janson RW AD - University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. AD - Denver Veterans Affairs Medical Center, Denver, CO, USA. LA - eng PT - Journal Article DEP - 20170908 PL - United States TA - J Investig Med High Impact Case Rep JT - Journal of investigative medicine high impact case reports JID - 101624758 PMC - PMC5917447 OTO - NOTNLM OT - diabetes mellitus OT - etanercept OT - hypoglycemia OT - psoriatic arthritis COIS- Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2018/05/04 06:00 MHDA- 2018/05/04 06:01 PMCR- 2017/09/08 CRDT- 2018/05/04 06:00 PHST- 2017/06/15 00:00 [received] PHST- 2017/07/20 00:00 [revised] PHST- 2017/07/29 00:00 [accepted] PHST- 2018/05/04 06:00 [entrez] PHST- 2018/05/04 06:00 [pubmed] PHST- 2018/05/04 06:01 [medline] PHST- 2017/09/08 00:00 [pmc-release] AID - 10.1177_2324709617727760 [pii] AID - 10.1177/2324709617727760 [doi] PST - epublish SO - J Investig Med High Impact Case Rep. 2017 Sep 8;5(3):2324709617727760. doi: 10.1177/2324709617727760. eCollection 2017 Jul-Sep.