PMID- 29721768 OWN - NLM STAT- MEDLINE DCOM- 20190812 LR - 20200401 IS - 1931-7565 (Electronic) IS - 1931-7557 (Print) IS - 1931-7557 (Linking) VI - 13 IP - 2 DP - 2019 Apr TI - Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention. PG - 482-492 LID - 10.1007/s11682-018-9875-3 [doi] AB - This study examines altered resting state functional connectivity (rsFC) of the cognitive control network (CCN) in fibromyalgia patients as compared to healthy controls, as well as how an effective mind-body intervention, Tai Chi, can modulate the altered rsFC of the CCN. Patients with fibromyalgia and matched healthy subjects were recruited in this study. Fibromyalgia patients were scanned 12 weeks before and after intervention. The bilateral dorsolateral prefrontal cortex (DLPFC) was used as a seed to explore the rsFC of the CCN. Data analysis was conducted with 21 patients and 20 healthy subjects. Compared to healthy subjects, fibromyalgia patients exhibited increased rsFC between the DLPFC and the bilateral rostral anterior cingulate cortex (rACC) and medial prefrontal cortex (MPFC) at baseline. The rsFC between the CCN and rACC/MPFC further increased after Tai Chi intervention, and this increase was accompanied by clinical improvements. This rsFC change was also significantly associated with corresponding changes in the Overall Impact domain of the Revised Fibromyalgia Impact Questionnaire (FIQR). Further analysis showed that the rACC/MPFC rsFC with both the PAG and hippocampus significantly decreased following Tai Chi intervention. Our study suggests that fibromyalgia is associated with altered CCN rsFC and that effective mind-body treatment may elicit clinical improvements by further increasing this altered rsFC. Elucidating this mechanism of enhancing the allostasis process will deepen our understanding of the mechanisms underlying mind-body interventions in fibromyalgia patients and facilitate the development of new pain management methods. FAU - Kong, Jian AU - Kong J AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. kongj@nmr.mgh.harvard.edu. FAU - Wolcott, Emily AU - Wolcott E AD - Center For Complementary And Integrative Medicine, Department of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA. FAU - Wang, Zengjian AU - Wang Z AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. FAU - Jorgenson, Kristen AU - Jorgenson K AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. FAU - Harvey, William F AU - Harvey WF AD - Center For Complementary And Integrative Medicine, Department of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA. FAU - Tao, Jing AU - Tao J AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. FAU - Rones, Ramel AU - Rones R AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. FAU - Wang, Chenchen AU - Wang C AD - Center For Complementary And Integrative Medicine, Department of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA. cwang2@tuftsmedicalcenter.org. LA - eng GR - UL1TR000073/National Center for Advancing Translational Sciences/ GR - R21 AT008707/AT/NCCIH NIH HHS/United States GR - R01 AT005521/National Center for Research Resources/ GR - R61 AT009310/AT/NCCIH NIH HHS/United States GR - UL1TR001064/National Center for Advancing Translational Sciences/ GR - R01 AT006364/AT/NCCIH NIH HHS/United States GR - R01AT006364/National Center for Complementary and Integrative Health/ GR - R61 AT009310/National Center for Complementary and Integrative Health/ GR - UL1 TR001064/TR/NCATS NIH HHS/United States GR - R01AT008563/National Center for Complementary and Integrative Health/ GR - K24 AT007323/AT/NCCIH NIH HHS/United States GR - UL1 RR025752/RR/NCRR NIH HHS/United States GR - R01 AT008563/AT/NCCIH NIH HHS/United States GR - R01 AT006367/AT/NCCIH NIH HHS/United States GR - UL1 TR000073/TR/NCATS NIH HHS/United States GR - P01AT006663/National Center for Complementary and Integrative Health/ GR - P01 AT006663/AT/NCCIH NIH HHS/United States GR - R01AT006367/National Center for Research Resources/ GR - UL1 RR025752/National Institutes of Health/ GR - R21AT008707/National Center for Complementary and Integrative Health/ GR - K24 AT007323/National Center for Research Resources/ GR - R01 AT005521/AT/NCCIH NIH HHS/United States PT - Journal Article PL - United States TA - Brain Imaging Behav JT - Brain imaging and behavior JID - 101300405 MH - Brain Mapping/*methods MH - Female MH - Fibromyalgia/*therapy MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neural Pathways/*physiopathology MH - *Rest MH - Tai Ji/*methods PMC - PMC6214794 MID - NIHMS964786 OTO - NOTNLM OT - Anterior cingulate cortex OT - Cognitive control network OT - Dorsal lateral prefrontal cortex OT - Fibromyalgia OT - Mind-body intervention OT - Resting state functional connectivity OT - Tai Chi COIS- Conflict of interest Jian Kong holds equity of a start-up Inc (MNT). All authors declare that they have no competing financial interests. EDAT- 2018/05/04 06:00 MHDA- 2019/08/14 06:00 PMCR- 2020/04/01 CRDT- 2018/05/04 06:00 PHST- 2018/05/04 06:00 [pubmed] PHST- 2019/08/14 06:00 [medline] PHST- 2018/05/04 06:00 [entrez] PHST- 2020/04/01 00:00 [pmc-release] AID - 10.1007/s11682-018-9875-3 [pii] AID - 10.1007/s11682-018-9875-3 [doi] PST - ppublish SO - Brain Imaging Behav. 2019 Apr;13(2):482-492. doi: 10.1007/s11682-018-9875-3.