PMID- 29721977
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1074
DP  - 2018
TI  - Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.
PG  - 465-471
LID - 10.1007/978-3-319-75402-4_57 [doi]
AB  - This review discusses the therapeutic potential of brain-derived neurotrophic 
      factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), 
      neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These 
      neuronal modulators activate a common receptor and a specific tropomyosin-related 
      kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in 
      models of retinal degeneration as early as 1992. However, development of 
      effective therapeutics that exploit this pathway has been difficult due to 
      challenges in sustaining therapeutic levels in the retina.
FAU - Daly, Conor
AU  - Daly C
AD  - School of Biomolecular and Biomedical Science, University College Dublin, 
      Belfield, Ireland.
FAU - Ward, Rebecca
AU  - Ward R
AD  - School of Biomolecular and Biomedical Science, University College Dublin, 
      Belfield, Ireland.
FAU - Reynolds, Alison L
AU  - Reynolds AL
AD  - School of Veterinary Medicine, University College Dublin, Belfield, Ireland.
FAU - Galvin, Orla
AU  - Galvin O
AD  - School of Biomolecular and Biomedical Science, University College Dublin, 
      Belfield, Ireland.
AD  - RenaSci Limited, BioCity, Nottingham, UK.
FAU - Collery, Ross F
AU  - Collery RF
AD  - Department of Ophthalmology and Visual Sciences, Eye Institute, Medical College 
      of Wisconsin, Milwaukee, WI, USA.
FAU - Kennedy, Breandan N
AU  - Kennedy BN
AD  - School of Biomolecular and Biomedical Science, University College Dublin, 
      Belfield, Ireland. brendan.kennedy@ucd.ie.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/pharmacokinetics/*therapeutic use
MH  - Cell Survival/drug effects
MH  - Dependovirus/genetics
MH  - Disease Models, Animal
MH  - Drug Evaluation, Preclinical
MH  - Genetic Therapy
MH  - Genetic Vectors/therapeutic use
MH  - Humans
MH  - Mice
MH  - Neuroprotective Agents/pharmacokinetics/*therapeutic use
MH  - Photoreceptor Cells, Vertebrate/drug effects
MH  - Rats
MH  - Recombinant Proteins/pharmacokinetics/therapeutic use
MH  - Retinal Degeneration/*drug therapy/prevention & control/therapy
OTO - NOTNLM
OT  - BDNF
OT  - Brain-Derived Neurotrophic Factor
OT  - Neuroprotection
OT  - Photoreceptor
OT  - Retinal degeneration
EDAT- 2018/05/04 06:00
MHDA- 2019/05/07 06:00
CRDT- 2018/05/04 06:00
PHST- 2018/05/04 06:00 [entrez]
PHST- 2018/05/04 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
AID - 10.1007/978-3-319-75402-4_57 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1074:465-471. doi: 10.1007/978-3-319-75402-4_57.