PMID- 29722303
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 13
IP  - 4
DP  - 2018 Apr
TI  - Harnessing migraines for neural regeneration.
PG  - 609-615
LID - 10.4103/1673-5374.230275 [doi]
AB  - The success of naturalistic or therapeutic neuroregeneration likely depends on an 
      internal milieu that facilitates the survival, proliferation, migration, and 
      differentiation of stem cells and their assimilation into neural networks. 
      Migraine attacks are an integrated sequence of physiological processes that may 
      protect the brain from oxidative stress by releasing growth factors, suppressing 
      apoptosis, stimulating neurogenesis, encouraging mitochondrial biogenesis, 
      reducing the production of oxidants, and upregulating antioxidant defenses. Thus, 
      the migraine attack may constitute a physiologic environment conducive to stem 
      cells. In this paper, key components of migraine are reviewed - neurogenic 
      inflammation with release of calcitonin gene-related peptide (CGRP) and substance 
      P, plasma protein extravasation, platelet activation, release of serotonin by 
      platelets and likely by the dorsal raphe nucleus, activation of endothelial 
      nitric oxide synthase (eNOS), production of brain-derived neurotrophic factor 
      (BDNF) and, in migraine aura, cortical spreading depression - along with their 
      potential neurorestorative aspects. The possibility is considered of using these 
      components to facilitate successful stem cell transplantation. Potential methods 
      for doing so are discussed, including chemical stimulation of the TRPA1 ion 
      channel, conjoint activation of a subset of migraine components, invasive and 
      noninvasive deep brain stimulation of the dorsal raphe nucleus, transcranial 
      focused ultrasound, and stimulation of the Zusanli (ST36) acupuncture point.
FAU - Borkum, Jonathan M
AU  - Borkum JM
AD  - Department of Psychology, University of Maine, Orono; Health Psych Maine, 
      Waterville, ME, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC5950661
OTO - NOTNLM
OT  - acupuncture
OT  - albumin
OT  - calcitonin gene-related peptide
OT  - migraine
OT  - neurogenesis
OT  - neuroprotection
OT  - neurorestoration
OT  - oxidative stress
OT  - stem cells
OT  - transient receptor potential ankyrin-1
COIS- The authors declare that there is no conflict of interest
EDAT- 2018/05/04 06:00
MHDA- 2018/05/04 06:01
PMCR- 2018/04/01
CRDT- 2018/05/04 06:00
PHST- 2018/05/04 06:00 [entrez]
PHST- 2018/05/04 06:00 [pubmed]
PHST- 2018/05/04 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - NeuralRegenRes_2018_13_4_609_230275 [pii]
AID - NRR-13-609 [pii]
AID - 10.4103/1673-5374.230275 [doi]
PST - ppublish
SO  - Neural Regen Res. 2018 Apr;13(4):609-615. doi: 10.4103/1673-5374.230275.