PMID- 29722625
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20191112
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 125
IP  - 2
DP  - 2018 Aug 1
TI  - Microvascularization is not a limiting factor for exercise in adults with 
      cerebral palsy.
PG  - 536-544
LID - 10.1152/japplphysiol.00827.2017 [doi]
AB  - Muscle contractures are a common complication in patients with central nervous 
      system (CNS) lesions which limit range of movement and cause joint deformities. 
      Furthermore, it has previously been shown that muscles with contractures have a 
      reduced number of capillaries, indicating decreased tissue vascularization. The 
      aim of the present study was to investigate the microvascular volume (MV) at rest 
      and after acute exercise in the muscle tissue of individuals with cerebral palsy 
      (CP) and healthy control individuals. Contrast-enhanced ultrasound (CEUS) was 
      used before and after 30 min of walking or running on a treadmill in 10 healthy 
      control participants and 10 individuals with CP to detect MV of their skeletal 
      muscle tissue. A significant increase in the MV was observed after exercise both 
      in the adult CP group (21-53 yr) and in the control group (21-52 yr) (1.8 +/- 0.8 
      DeltadB to 3.1 +/- 0.9 DeltadB or 42.9% and 1.5 +/- 0.6 DeltadB to 2.5 +/- 0.9 DeltadB or 39.0%, 
      respectively). Furthermore, a difference in the resting MV was observed between 
      the most severe cases of CP [gross motor function classification scale (GMFCS) 3 
      and 4] (2.3 +/- 0.5 DeltadB) and the less severe cases (GMFCS 1 and 2) (1.5 +/- 0.2 DeltadB). 
      When the CP group was walking (3.4 km/h), the lactate levels, Borg score, and 
      heart rate matched the level of controls when they were running (9.8 km/h). In 
      conclusion, individuals with CP become exhausted at much lower exercise 
      intensities than healthy individuals. This is not explained by impaired 
      microvascularization, since the MV of the individuals with CP respond normally to 
      increased O(2) demand during acute exercise. NEW & NOTEWORTHY Cerebral palsy (CP) 
      patients were less physically active compared with typically developed 
      individuals. This may affect the microvascularization. We observed that the CP 
      group became exhausted at much lower exercise intensities compared with healthy 
      individuals. However, impaired microvascularization was not the reason for the 
      decreased physical activity as the CP group responded normally to increased O(2) 
      demand during acute exercise. These results indicate that walking may be 
      recommended as an intervention to train and maintain skeletal muscle tissue in 
      individuals with CP.
FAU - Andersen, Ida Torp
AU  - Andersen IT
AD  - Center for Neuroscience, Copenhagen University , Copenhagen , Denmark.
FAU - Harrison, Adrian
AU  - Harrison A
AD  - MyoDynamik ApS, Copenhagen , Denmark.
AD  - Department of Veterinary & Animal Sciences, Faculty of Health & Medical Sciences, 
      Copenhagen University , Copenhagen , Denmark.
FAU - Broholm, Rikke
AU  - Broholm R
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and 
      Frederiksberg Hospital, Copenhagen University , Copenhagen , Denmark.
FAU - Harder, Anja
AU  - Harder A
AD  - MyoDynamik ApS, Copenhagen , Denmark.
FAU - Nielsen, Jens Bo
AU  - Nielsen JB
AUID- ORCID: 0000-0001-5568-2916
AD  - Center for Neuroscience, Copenhagen University , Copenhagen , Denmark.
FAU - Bulow, Jens
AU  - Bulow J
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and 
      Frederiksberg Hospital, Copenhagen University , Copenhagen , Denmark.
AD  - Department of Biomedical Sciences, Copenhagen University , Copenhagen , Denmark.
FAU - Pingel, Jessica
AU  - Pingel J
AUID- ORCID: 0000-0002-9977-094X
AD  - Center for Neuroscience, Copenhagen University , Copenhagen , Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180503
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cerebral Palsy/*physiopathology
MH  - Exercise/*physiology
MH  - Exercise Test/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Microvessels/*physiopathology
MH  - Middle Aged
MH  - Muscle Spasticity/physiopathology
MH  - Muscle, Skeletal/physiopathology
MH  - Neovascularization, Physiologic/*physiology
MH  - Running/physiology
MH  - Walking/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - cerebral palsy
OT  - microvascularization
OT  - muscle contractures
EDAT- 2018/05/04 06:00
MHDA- 2019/11/13 06:00
CRDT- 2018/05/04 06:00
PHST- 2018/05/04 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/05/04 06:00 [entrez]
AID - 10.1152/japplphysiol.00827.2017 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2018 Aug 1;125(2):536-544. doi: 
      10.1152/japplphysiol.00827.2017. Epub 2018 May 3.