PMID- 29724398
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 138
DP  - 2018 May
TI  - Determinants of functional, peak and endurance exercise capacity in people with 
      chronic obstructive pulmonary disease.
PG  - 81-87
LID - S0954-6111(18)30104-5 [pii]
LID - 10.1016/j.rmed.2018.03.032 [doi]
AB  - BACKGROUND: Exercise limitation in COPD is multi-factorial. The contribution of 
      cardiac function to exercise capacity is not clear. METHODS: Potential 
      determinants of the different constructs of exercise capacity (functional, peak 
      and endurance exercise capacity using the 6-minute walk distance (6MWD), peak 
      oxygen uptake (VO(2)peak) and peak work load, and sub-maximal constant work rate 
      test (CWRT) cycle time, respectively) were analysed. RESULTS: Data were collected 
      in 516 people with COPD (56% male, age (mean +/- SD) 64 +/- 9 years, FEV(1)% 
      predicted 49 +/- 20%). Participants had reduced exercise capacity (6MWD 
      424 +/- 124 m, 67 +/- 18% predicted; VO(2)peak 1090 +/- 414 ml/min, 66 +/- 30% predicted; 
      peak work load 70 +/- 34 watts, 56 +/- 27% predicted; CWRT cycle time (median (IQR)) 
      225 (169-328) seconds). Cardiac function measures, including echocardiography and 
      N-terminal pro-brain natriuretic peptide level, were independently significantly 
      correlated with exercise capacity. In multiple regression analyses adjusted for 
      age and gender, 72% (p < 0.001) of the 6MWD variance could be explained, with the 
      timed up-and-go test accounting for 32% of the variance. For VO(2)peak, 60% 
      (p < 0.001) of the variance could be explained, with FEV(1) accounting for 30% of 
      the variance. Quadriceps total work was a significant determinant of all exercise 
      tests. CONCLUSIONS: Cardiac function is related to exercise capacity, however is 
      not a primary determinant. Determinants of the different constructs of exercise 
      capacity vary, but there is a strong relationship between quadriceps force and 
      functional and endurance exercise performance, and between lung function and peak 
      exercise capacity.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - McNamara, Renae J
AU  - McNamara RJ
AD  - Department of Research and Education, CIRO, Horn, The Netherlands; Departments of 
      Respiratory and Sleep Medicine and Physiotherapy, Prince of Wales Hospital, 
      Randwick, Australia. Electronic address: renae.mcnamara@health.nsw.gov.au.
FAU - Houben-Wilke, Sarah
AU  - Houben-Wilke S
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: sarahwilke@ciro-horn.nl.
FAU - Franssen, Frits M E
AU  - Franssen FME
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: fritsfranssen@ciro-horn.nl.
FAU - Smid, Dionne E
AU  - Smid DE
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: dionnesmid@ciro-horn.nl.
FAU - Vanfleteren, Lowie E G W
AU  - Vanfleteren LEGW
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: lowievanfleteren@ciro-horn.nl.
FAU - Groenen, Miriam T J
AU  - Groenen MTJ
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: miriangroenen@ciro-horn.nl.
FAU - Uszko-Lencer, Nicole H M K
AU  - Uszko-Lencer NHMK
AD  - Department of Research and Education, CIRO, Horn, The Netherlands. Electronic 
      address: nicolelencer@ciro-horn.nl.
FAU - Wouters, Emiel F M
AU  - Wouters EFM
AD  - Department of Research and Education, CIRO, Horn, The Netherlands; Department of 
      Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, 
      The Netherlands. Electronic address: ewouters@ciro-horn.nl.
FAU - Alison, Jennifer A
AU  - Alison JA
AD  - Discipline of Physiotherapy, The University of Sydney, Lidcombe, Australia. 
      Electronic address: jennifer.alison@sydney.edu.au.
FAU - Spruit, Martijn A
AU  - Spruit MA
AD  - Department of Research and Education, CIRO, Horn, The Netherlands; Department of 
      Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of 
      Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands. 
      Electronic address: martijnspruit@ciro-horn.nl.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180329
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Echocardiography, Doppler
MH  - Exercise/*physiology
MH  - Exercise Test/methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Heart Diseases/complications/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/complications/*physiopathology
MH  - Respiratory Muscles/physiopathology
MH  - Severity of Illness Index
MH  - Vital Capacity/physiology
OTO - NOTNLM
OT  - Cardiac
OT  - Chronic obstructive pulmonary disease
OT  - Determinants
OT  - Echocardiography
OT  - Exercise capacity
OT  - Lung function
EDAT- 2018/05/05 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/05/05 06:00
PHST- 2017/11/07 00:00 [received]
PHST- 2018/02/22 00:00 [revised]
PHST- 2018/03/28 00:00 [accepted]
PHST- 2018/05/05 06:00 [entrez]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - S0954-6111(18)30104-5 [pii]
AID - 10.1016/j.rmed.2018.03.032 [doi]
PST - ppublish
SO  - Respir Med. 2018 May;138:81-87. doi: 10.1016/j.rmed.2018.03.032. Epub 2018 Mar 
      29.