PMID- 29725361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 5
DP  - 2018 May
TI  - Predictors of decreased left ventricular function subsequent to follow-up 
      echocardiography after percutaneous coronary intervention following acute 
      ST-elevation myocardial infarction.
PG  - 4089-4096
LID - 10.3892/etm.2018.5962 [doi]
AB  - The preferred treatment for patients with ST elevation myocardial infarction 
      (STEMI) is primary percutaneous coronary intervention (PCI). However, not all 
      patients improve or maintain heart function following primary PCI, and certain 
      patients may experience decreased heart function. The present study investigated 
      factors associated with left ventricular (LV) dysfunction, and improvement or 
      deterioration of LV ejection fraction (LVEF) at follow-up echocardiography 
      following successful primary PCI. The clinical outcomes following primary PCI 
      were also investigated. The present study assessed 4,044 patients who underwent 
      primary PCI following a diagnosis of STEMI between January 2008 and March 2012. A 
      total of 1,736 patients who underwent echocardiography between 30 days and 1 year 
      after STEMI and PCI, and who had completed clinical follow-up, were included in 
      the present study. A total of 243 patients (14.0%) demonstrated LV dysfunction at 
      follow-up echocardiography. Multivariate analysis revealed that LV dysfunction 
      (</=40%) at index STEMI, LVEF at index admission, renal insufficiency (creatinine 
      >/=1.4 mg/dl), peak creatine kinase (CK) and peak CK MB isoenzyme (CKMB) were 
      independent predictors of LV dysfunction at follow-up. Independent predictors for 
      the deterioration of LVEF at follow-up were dyslipidemia, LVEF at index 
      admission, LVEF </=40% at index admission, peak CK and peak troponin-I. 
      Furthermore, being male, having no history of coronary artery disease, 
      pre-thrombolysis in myocardial infarction (TIMI) flow, LVEF at index admission, 
      LVEF </=40% at index admission, peak CKMB and peak troponin I were independent 
      predictors of LVEF improvement at follow-up. One-year major adverse cardiac 
      events were significantly increased in the LV dysfunction group compared with 
      patients who did not exhibit LV dysfunction according to Cox regression analysis 
      (13.6 vs. 20.4%; P=0.017). Therefore, the present study may provide valuable 
      prognostic information for clinicians to advise patients who experience LV 
      dysfunction despite having undergone successful primary PCI. Additional 
      management is required in patients with these high-risk features following STEMI.
FAU - Kim, Dong-Hee
AU  - Kim DH
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Park, Chang-Bum
AU  - Park CB
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Jin, Eun-Sun
AU  - Jin ES
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Hwang, Hui-Jeong
AU  - Hwang HJ
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Sohn, Il Suk
AU  - Sohn IS
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Cho, Jin-Man
AU  - Cho JM
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
FAU - Kim, Chong-Jin
AU  - Kim CJ
AD  - Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee 
      University, Seoul 05278, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180319
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5920495
OTO - NOTNLM
OT  - angioplasty
OT  - coronary occlusion
OT  - myocardial infarction
EDAT- 2018/05/05 06:00
MHDA- 2018/05/05 06:01
PMCR- 2018/03/19
CRDT- 2018/05/05 06:00
PHST- 2016/03/06 00:00 [received]
PHST- 2017/02/24 00:00 [accepted]
PHST- 2018/05/05 06:00 [entrez]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/05/05 06:01 [medline]
PHST- 2018/03/19 00:00 [pmc-release]
AID - ETM-0-0-5962 [pii]
AID - 10.3892/etm.2018.5962 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 May;15(5):4089-4096. doi: 10.3892/etm.2018.5962. Epub 2018 Mar 
      19.