PMID- 29725390
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 5
DP  - 2018 May
TI  - Effect of gastric bypass combined with ileal transportation on type 2 diabetes 
      mellitus.
PG  - 4571-4577
LID - 10.3892/etm.2018.5928 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic progressive disease, which manifests 
      as an endocrine disorder. Among the different methods of surgery available to 
      treat patients with T2DM, Roux-en-Y gastric bypass (RYGBP) and ileal 
      transposition (IT) are the most commonly performed. The aim of the present study 
      was to investigate the effects of RYGBP combined with IT on rats with T2DM. A 
      total of 8 healthy male rats were used as a control group and 40 GK rats were 
      randomly divided into 5 groups: A diabetes mellitus (DM) group, a sham operative 
      group (SO), a RYGBP group, an IT group and a RYGBP+IT group. The results 
      demonstrated that fasting blood glucose, triglyceride, total cholesterol and 
      gastric inhibitory polypeptide levels in all treatment groups were significantly 
      lower than those of the SO and DM groups. Furthermore, levels TC and TG in the 
      RYGBP+IT group were significantly lower than in the RYGBP and IT groups. Levels 
      of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase mRNA and IRS-2 
      protein in all treatment groups were also significantly lower than those of the 
      SO group; and they were significantly lower in the RYGBP+IT group compared with 
      the RYGBP and IT groups. The expression of phosphorylated Akt in the treatment 
      groups was significantly higher than the SO group and was significantly higher in 
      the RYGBP+IT group compared with the RYGBP and IT groups. These results indicate 
      that RYGBP and IT surgical treatment can induce T2DM remission by mediating the 
      expression of insulin-related factors to reverse insulin resistance. The current 
      study also indicated that the effect of RYGBP combined with IT may be developed 
      as a novel first-line method of treating T2DM.
FAU - Gao, Zhaoxia
AU  - Gao Z
AD  - Department of General Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Ear-Nose-Throat, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Gong, Xiaojun
AU  - Gong X
AD  - Department of General Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Yao, Chun
AU  - Yao C
AD  - Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Ren, Defa
AU  - Ren D
AD  - Department of General Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Shao, Liwei
AU  - Shao L
AD  - Department of General Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
FAU - Pang, Yan
AU  - Pang Y
AD  - Department of Clinical Laboratory, The Fifth Hospital of Wuhan, Wuhan, Hubei 
      430050, P.R. China.
FAU - Liu, Jinxiu
AU  - Liu J
AD  - Department of General Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180306
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5920358
OTO - NOTNLM
OT  - gastric bypass
OT  - ileal transportation
OT  - insulin resistance
OT  - type 2 diabetes
EDAT- 2018/05/05 06:00
MHDA- 2018/05/05 06:01
PMCR- 2018/03/06
CRDT- 2018/05/05 06:00
PHST- 2017/04/08 00:00 [received]
PHST- 2017/12/08 00:00 [accepted]
PHST- 2018/05/05 06:00 [entrez]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/05/05 06:01 [medline]
PHST- 2018/03/06 00:00 [pmc-release]
AID - ETM-0-0-5928 [pii]
AID - 10.3892/etm.2018.5928 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 May;15(5):4571-4577. doi: 10.3892/etm.2018.5928. Epub 2018 Mar 
      6.