PMID- 29725526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 8
IP  - 5
DP  - 2018 May
TI  - Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance 
      and prevention of type 2 diabetes mellitus in non-diabetics: A systematic review 
      and meta-analysis.
PG  - 475-484
LID - 10.3892/br.2018.1074 [doi]
AB  - Increasing epidemiological studies suggest that there is an association between 
      vitamin D deficiency and risk of type 2 diabetes mellitus (T2DM). Therefore, 
      randomized clinical trials (RCTs) have been performed to observe the effect of 
      vitamin D supplementation on preventing T2DM, decreasing fasting plasma glucose 
      (FPG) and improving insulin resistance to confirm the association between vitamin 
      D and T2DM. However, the results of RCTs on controlling FPG level, improving 
      insulin resistance and preventing T2DM in non-diabetics are inconsistent. In the 
      present study, a systematic meta-analysis considering individual variation and 
      intervention strategy was conducted to establish an objective and definitive 
      conclusion. The results suggested that vitamin D supplementation had no 
      significant effect on controlling FPG level, improving insulin resistance or 
      preventing T2DM in non-diabetics in a pooled meta-analysis of 23 articles 
      (containing 28 RCTs). However, stratified analysis indicated that supplementation 
      of vitamin D had differential effects on FPG control, insulin sensitivity 
      improvement and T2DM prevention in individuals with different baseline states: 
      FPG was decreased for those with BMI <25 (P=0.048) or 20</= 25(OH)D <30 ng/ml 
      (P=0.002); insulin resistance was improved for those with 25(OH)D >/=30 ng/ml 
      (P=0.021); and risk of T2DM was lower for pre-diabetic individuals (P=0.047) or 
      for those with 25</= BMI <30 (P=0.032). Additionally, the effect on T2DM prevention 
      was improved when the supplement dose was >2,000 IU/day (P=0.047) and with 
      intervention without calcium (P=0.047). Thus, further trials should focus on 
      individual baselines and the supplementation strategy of vitamin D in the 
      prevention of T2DM.
FAU - He, Sitian
AU  - He S
AD  - Department of Sanitary Chemistry, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan 450001, P.R. China.
FAU - Yu, Songcheng
AU  - Yu S
AD  - Department of Sanitary Chemistry, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan 450001, P.R. China.
FAU - Zhou, Zonglei
AU  - Zhou Z
AD  - Department of Sanitary Chemistry, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan 450001, P.R. China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Statistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan 450001, P.R. China.
FAU - Wu, Yongjun
AU  - Wu Y
AD  - Department of Sanitary Chemistry, College of Public Health, Zhengzhou University, 
      Zhengzhou, Henan 450001, P.R. China.
FAU - Li, Wenjie
AU  - Li W
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan 450001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180309
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC5920274
OTO - NOTNLM
OT  - fasting plasma glucose
OT  - insulin resistance
OT  - meta-analysis
OT  - type 2 diabetes mellitus
OT  - vitamin D
EDAT- 2018/05/05 06:00
MHDA- 2018/05/05 06:01
PMCR- 2018/03/09
CRDT- 2018/05/05 06:00
PHST- 2017/11/07 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/05/05 06:00 [entrez]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/05/05 06:01 [medline]
PHST- 2018/03/09 00:00 [pmc-release]
AID - BR-0-0-1074 [pii]
AID - 10.3892/br.2018.1074 [doi]
PST - ppublish
SO  - Biomed Rep. 2018 May;8(5):475-484. doi: 10.3892/br.2018.1074. Epub 2018 Mar 9.