PMID- 29726700
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 10
DP  - 2018 Oct
TI  - Acute exercise induced BDNF-TrkB signalling is intact in the prefrontal cortex of 
      obese, glucose-intolerant male mice.
PG  - 1083-1089
LID - 10.1139/apnm-2018-0108 [doi]
AB  - Obesity and glucose intolerance have been directly implicated in the pathology of 
      Alzheimer's disease. It is thought that diet-induced obesity causes a reduction 
      in neuronal plasticity through a reduction in the neurotrophin: brain-derived 
      neurotrophic factor (BDNF). Previous work has demonstrated that acute exercise in 
      healthy lean animals increases BDNF-TrkB signalling in the brain. However, if 
      this effect is intact in a state of obesity remains unknown. The purpose of this 
      study is to determine the effects of a single bout of exercise on BDNF-TrkB 
      signalling in the prefrontal cortex and hippocampus from obese glucose intolerant 
      mice. Male C57BL/6 mice were fed a low-fat diet (10% kcals from lard) or a 
      high-fat diet (HFD, 60% kcals from lard) for 7 weeks. A subset of HFD mice 
      underwent an acute bout of exercise (treadmill running: 15 m/min, 5% incline, 120 
      min) followed by a recovery period of 2 h, after which point the prefrontal 
      cortex and hippocampus were collected. The HFD increased body mass and glucose 
      intolerance (p < 0.05). Prefrontal cortex from HFD mice demonstrated lower BDNF 
      protein content, reduced phosphorylation of the BDNF receptor (TrkB), and its 
      downstream effector cAMP response element-binding protein (CREB), as well as 
      PGC-1alpha and ERalpha) protein content (p < 0.05). Two hours following the acute 
      exercise bout, TrkB and CREB phosphorylation as well as PGC-1alpha and ER-alpha protein 
      content were recovered (p < 0.05). Our findings demonstrate for the first time 
      that an acute bout of exercise can recover BDNF-TrkB signalling in the prefrontal 
      cortex of obese mice.
FAU - Baranowski, Bradley J
AU  - Baranowski BJ
AD  - a Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - MacPherson, Rebecca E K
AU  - MacPherson REK
AD  - a Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
AD  - b Centre for Neuroscience, Brock University, St. Catharines, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180504
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Diet, Fat-Restricted
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Estrogen Receptor alpha/metabolism
MH  - Glucose Intolerance/*metabolism/physiopathology
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice, Inbred C57BL
MH  - Obesity/*metabolism/physiopathology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Phosphorylation
MH  - *Physical Exertion
MH  - Prefrontal Cortex/*metabolism/physiopathology
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - *Signal Transduction
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF
OT  - TrkB
OT  - cortex prefrontal
OT  - exercice physique
OT  - exercise
OT  - hippocampe
OT  - hippocampus
OT  - neurotrophin
OT  - neurotrophine
OT  - obesity
OT  - obesite
OT  - prefrontal cortex
EDAT- 2018/05/05 06:00
MHDA- 2019/01/29 06:00
CRDT- 2018/05/05 06:00
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/05/05 06:00 [entrez]
AID - 10.1139/apnm-2018-0108 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 Oct;43(10):1083-1089. doi: 10.1139/apnm-2018-0108. 
      Epub 2018 May 4.