PMID- 29727008
OWN - NLM
STAT- MEDLINE
DCOM- 20190104
LR  - 20190104
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 103
IP  - 7
DP  - 2018 Jul 1
TI  - Pro-FHH: A Risk Equation to Facilitate the Diagnosis of Parathyroid-Related 
      Hypercalcemia.
PG  - 2534-2542
LID - 10.1210/jc.2017-02773 [doi]
AB  - CONTEXT: Parathyroid-related hypercalcemia is due to primary hyperparathyroidism 
      (PHPT) or to familial hypocalciuric hypercalcemia (FHH). PHPT can lead to 
      complications that necessitate parathyroidectomy. FHH is a rare genetic disease 
      resembling PHPT; surgery is ineffective. A reliable method for distinguishing FHH 
      from PHPT is needed. OBJECTIVE: To develop an easy-to-use tool to predict if a 
      patient has PHPT. DESIGN: Retrospective analysis of two prospective cohorts. 
      Development of an unsupervised risk equation (Pro-FHH). SETTING: University 
      hospitals in Paris, France, and Aarhus, Denmark. PARTICIPANTS: Patients (Paris: 
      65 with FHH, 85 with PHPT; Aarhus: 38 with FHH, 55 with PHPT) were adults with 
      hypercalcemia and PTH concentration within normal range. MAIN OUTCOME MEASURES: 
      Performance of Pro-FHH to predict PHPT. RESULTS: Pro-FHH takes into account 
      plasma calcium, PTH, and serum osteocalcin concentrations, and 
      calcium-to-creatinine clearance ratio calculated from 24-hour urine collection 
      (24h-CCCR). In the Paris cohort, area under the receiver operating characteristic 
      curve (AUROC) of Pro-FHH was 0.961, higher than that of 24h-CCCR. With a cutoff 
      value of 0.928, Pro-FHH had 100% specificity and 100% positive predictive value 
      for the diagnosis of PHPT; it correctly categorized 51 of 85 patients with PHPT; 
      the remaining 34 were recommended to undergo genetic testing. No patients with 
      FHH were wrongly categorized. In an independent cohort from Aarhus, AUROC of 
      Pro-FHH was 0.951, higher than that of 24h-CCCR. CONCLUSION: Pro-FHH effectively 
      predicted whether a patient has PHPT. A prospective trial is necessary to assess 
      its usefulness in a larger population and in patients with elevated PTH 
      concentration.
FAU - Bertocchio, Jean-Philippe
AU  - Bertocchio JP
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Universite Paris Descartes, Faculte de Medecine, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
FAU - Tafflet, Muriel
AU  - Tafflet M
AD  - INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, 
      Sorbonne Paris Cite, UMR-S970, Paris, France.
FAU - Koumakis, Eugenie
AU  - Koumakis E
AD  - Assistance Publique-Hopitaux de Paris, Hopital Cochin, Service de Rhumatologie, 
      Paris, France.
FAU - Maruani, Gerard
AU  - Maruani G
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - Assistance Publique-Hopitaux de Paris, Institut Necker-Enfants Malades, INSERM 
      U1151 -CNRS UMR 8253, Paris, France.
FAU - Vargas-Poussou, Rosa
AU  - Vargas-Poussou R
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service 
      de Genetique, Paris, France.
FAU - Silve, Caroline
AU  - Silve C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Cochin, Biochimie et Genetique 
      Moleculaires, Paris, France.
AD  - INSERM, U1169, Universite Paris Sud, Hopital Bicetre, Le Kremlin Bicetre, France.
AD  - Centre de Reference des Maladies Rares du Metabolisme du Phosphore et du Calcium 
      Filiere de Sante Maladies Rares OSCAR, Paris, France.
FAU - Nissen, Peter H
AU  - Nissen PH
AD  - Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, 
      Denmark.
FAU - Baron, Stephanie
AU  - Baron S
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Universite Paris Descartes, Faculte de Medecine, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
FAU - Prot-Bertoye, Caroline
AU  - Prot-Bertoye C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Universite Paris Descartes, Faculte de Medecine, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
FAU - Courbebaisse, Marie
AU  - Courbebaisse M
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Universite Paris Descartes, Faculte de Medecine, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - Assistance Publique-Hopitaux de Paris, Institut Necker-Enfants Malades, INSERM 
      U1151 -CNRS UMR 8253, Paris, France.
FAU - Souberbielle, Jean-Claude
AU  - Souberbielle JC
AD  - Assistance Publique-Hopitaux de Paris, Institut Necker-Enfants Malades, 
      Laboratoires d'Explorations Fonctionnelles, Paris, France.
FAU - Rejnmark, Lars
AU  - Rejnmark L
AD  - Department of Endocrinology and Internal Medicine, THG, Aarhus University 
      Hospital, Aarhus C, Aarhus, Denmark.
FAU - Cormier, Catherine
AU  - Cormier C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Cochin, Service de Rhumatologie, 
      Paris, France.
FAU - Houillier, Pascal
AU  - Houillier P
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, 
      Departement de Physiologie, Paris, France.
AD  - Universite Paris Descartes, Faculte de Medecine, Paris, France.
AD  - Centre de Reference des Maladies Renales Hereditaires de l'Enfant et de l'Adulte, 
      Paris, France.
AD  - INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - CNRS, ERL8228, Paris, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Parathyroid Hormone)
RN  - 104982-03-8 (Osteocalcin)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
RN  - Hypocalciuric hypercalcemia, familial, type 1
SB  - IM
CIN - J Clin Endocrinol Metab. 2019 Feb 1;104(2):463-464. PMID: 30383233
CIN - J Clin Endocrinol Metab. 2019 Feb 1;104(2):461-462. PMID: 30388234
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Calcium/blood/urine
MH  - Creatinine/urine
MH  - Female
MH  - Humans
MH  - Hypercalcemia/complications/*congenital/*diagnosis/etiology
MH  - Hyperparathyroidism, Primary/complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/blood
MH  - Parathyroid Hormone/blood
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Assessment/*methods
MH  - Sensitivity and Specificity
EDAT- 2018/05/05 06:00
MHDA- 2019/01/05 06:00
CRDT- 2018/05/05 06:00
PHST- 2017/12/23 00:00 [received]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2019/01/05 06:00 [medline]
PHST- 2018/05/05 06:00 [entrez]
AID - 4990772 [pii]
AID - 10.1210/jc.2017-02773 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2018 Jul 1;103(7):2534-2542. doi: 10.1210/jc.2017-02773.