PMID- 29727764
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 53
DP  - 2018 Jul-Aug
TI  - Association of brain-derived neurotrophic factor and interleukin-6 serum levels 
      with depressive and anxiety symptoms in hemodialysis patients.
PG  - 25-31
LID - S0163-8343(17)30531-5 [pii]
LID - 10.1016/j.genhosppsych.2018.04.003 [doi]
AB  - OBJECTIVE: This study assessed the possible association of serum brain-derived 
      neurotrophic factor (BDNF) and interleukin-6 (IL-6) with depressive and anxiety 
      symptoms in hemodialysis (HD) patients. METHOD: An analytical cross-sectional 
      study was conducted over 274 HD patients from March to October 2017. The Hospital 
      Anxiety and Depression Scale (HADS) was utilized to evaluate depressive (HADS-D) 
      and anxiety (HADS-A) symptoms. The HADS-D/A is a self-report instrument that has 
      a maximum score of 21. Serum BDNF and IL-6 were measured using enzyme-linked 
      immunosorbant assay (ELISA). RESULTS: Serum IL-6 was significantly higher in 
      patients with depressive symptoms compared to normal (20.47 +/- 4.27 pg/mL for 
      HADS-D >/=11 versus 9.26 +/- 1.59 pg/mL for HADS-D <7, p = 0.014). Multivariable 
      regression analysis revealed that IL-6, education level, hypertension, and 
      dialysis duration were significant predictors of HADS-D. Also, gender, education 
      level, hypertension, and the number of dialysis sessions/week were significant 
      predictors of HADS-A. Significant positive correlation was shown between HADS-D 
      and IL-6 (r = 0.1729, p = 0.004). CONCLUSION: Collectively, HD patients with 
      depressive symptoms showed higher levels of IL-6, supporting previous findings 
      that the circulating inflammatory mediator IL-6 can be used as a biomarker for 
      prediction of depressive symptoms in HD patients. Further longitudinal or 
      interventional studies are needed to further validate this association.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Alshogran, Osama Y
AU  - Alshogran OY
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan. Electronic address: 
      oyalshogran@just.edu.jo.
FAU - Khalil, Amani A
AU  - Khalil AA
AD  - Department of Clinical Nursing, Faculty of Nursing, The University of Jordan, 
      Amman, Jordan.
FAU - Oweis, Ashraf O
AU  - Oweis AO
AD  - Department of Internal Medicine, Faculty of Medicine, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Altawalbeh, Shoroq M
AU  - Altawalbeh SM
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Alqudah, Mohammad A Y
AU  - Alqudah MAY
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180424
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anxiety/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Depression/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
MH  - Renal Insufficiency, Chronic/*blood/therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Anxiety
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Hemodialysis
OT  - Interleukin-6
EDAT- 2018/05/05 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/05/05 06:00
PHST- 2017/11/20 00:00 [received]
PHST- 2018/04/14 00:00 [revised]
PHST- 2018/04/22 00:00 [accepted]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/05/05 06:00 [entrez]
AID - S0163-8343(17)30531-5 [pii]
AID - 10.1016/j.genhosppsych.2018.04.003 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2018 Jul-Aug;53:25-31. doi: 
      10.1016/j.genhosppsych.2018.04.003. Epub 2018 Apr 24.