PMID- 29727771
OWN - NLM
STAT- MEDLINE
DCOM- 20180620
LR  - 20240318
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Print)
IS  - 0166-445X (Linking)
VI  - 200
DP  - 2018 Jul
TI  - Bifenthrin causes transcriptomic alterations in mTOR and ryanodine 
      receptor-dependent signaling and delayed hyperactivity in developing zebrafish 
      (Danio rerio).
PG  - 50-61
LID - S0166-445X(18)30073-0 [pii]
LID - 10.1016/j.aquatox.2018.04.003 [doi]
AB  - Over the last few decades, the pyrethroid insecticide bifenthrin has been 
      increasingly employed for pest control in urban and agricultural areas, putting 
      humans and wildlife at increased risk of exposure. Exposures to nanomolar (nM) 
      concentrations of bifenthrin have recently been reported to alter calcium 
      oscillations in rodent neurons. Neuronal calcium oscillations are influenced by 
      ryanodine receptor (RyR) activity, which modulates calcium-dependent signaling 
      cascades, including the mechanistic target of rapamycin (mTOR) signaling pathway. 
      RyR activity and mTOR signaling play critical roles in regulating 
      neurodevelopmental processes. However, whether environmentally relevant levels of 
      bifenthrin alter RyR or mTOR signaling pathways to influence neurodevelopment has 
      not been addressed. Therefore, our main objectives in this study were to examine 
      the transcriptomic responses of genes involved in RyR and mTOR signaling pathways 
      in zebrafish (Danio rerio) exposed to low (ng/L) concentrations of bifenthrin, 
      and to assess the potential functional consequences by measuring locomotor 
      responses to external stimuli. Wildtype zebrafish were exposed for 1, 3 and 5 
      days to 1, 10 and 50 ng/L bifenthrin, followed by a 14 d recovery period. 
      Bifenthrin elicited significant concentration-dependent transcriptional responses 
      in the majority of genes examined in both signaling cascades, and at all time 
      points examined during the acute exposure period (1, 3, and 5 days post 
      fertilization; dpf), and at the post recovery assessment time point (19 dpf). 
      Changes in locomotor behavior were not evident during the acute exposure period, 
      but were observed at 19 dpf, with main effects (increased locomotor behavior) 
      detected in fish exposed developmentally to bifenthrin at 1 or 10 ng/L, but not 
      50 ng/L. These findings illustrate significant influences of developmental 
      exposures to low (ng/L) concentrations of bifenthrin on neurodevelopmental 
      processes in zebrafish.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Frank, Daniel F
AU  - Frank DF
AD  - Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University 
      of California, Davis, CA 95616, USA; Aquatic Systems Biology, Department of 
      Ecology and Ecosystem Management, Technical University of Munich, Muhlenweg 22, 
      D-85354 Freising, Germany.
FAU - Miller, Galen W
AU  - Miller GW
AD  - Molecular Biosciences, School of Veterinary Medicine, University of California, 
      Davis, CA 95616, USA.
FAU - Harvey, Danielle J
AU  - Harvey DJ
AD  - Department of Public Health Sciences, Division of Biostatistics, University of 
      California, Davis, CA 95616, USA.
FAU - Brander, Susanne M
AU  - Brander SM
AD  - Biology & Marine Biology, University of North Carolina, Wilmington, NC 28403, 
      USA.
FAU - Geist, Juergen
AU  - Geist J
AD  - Aquatic Systems Biology, Department of Ecology and Ecosystem Management, 
      Technical University of Munich, Muhlenweg 22, D-85354 Freising, Germany.
FAU - Connon, Richard E
AU  - Connon RE
AD  - Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University 
      of California, Davis, CA 95616, USA.
FAU - Lein, Pamela J
AU  - Lein PJ
AD  - Molecular Biosciences, School of Veterinary Medicine, University of California, 
      Davis, CA 95616, USA. Electronic address: pjlein@ucdavis.edu.
LA  - eng
GR  - F32 ES024070/ES/NIEHS NIH HHS/United States
GR  - P30 ES005605/ES/NIEHS NIH HHS/United States
GR  - R01 ES014901/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20180418
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Pyrethrins)
RN  - 0 (Ryanodine Receptor Calcium Release Channel)
RN  - 0 (Water Pollutants, Chemical)
RN  - 6B66JED0KN (bifenthrin)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Hypersensitivity, Delayed/etiology/metabolism
MH  - Locomotion/drug effects
MH  - Pyrethrins/*toxicity
MH  - Ryanodine Receptor Calcium Release Channel/*metabolism
MH  - Signal Transduction/*drug effects
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Transcriptome/*drug effects
MH  - Water Pollutants, Chemical/*toxicity
MH  - Zebrafish/growth & development/*metabolism
PMC - PMC5992106
MID - NIHMS964884
OTO - NOTNLM
OT  - Ca2+-dependent signaling
OT  - Fish behavior
OT  - Insecticide
OT  - Neurodevelopment
OT  - Pesticide
OT  - Pyrethroid
EDAT- 2018/05/05 06:00
MHDA- 2018/06/21 06:00
PMCR- 2019/07/01
CRDT- 2018/05/05 06:00
PHST- 2018/02/02 00:00 [received]
PHST- 2018/04/06 00:00 [revised]
PHST- 2018/04/09 00:00 [accepted]
PHST- 2018/05/05 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2018/05/05 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S0166-445X(18)30073-0 [pii]
AID - 10.1016/j.aquatox.2018.04.003 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2018 Jul;200:50-61. doi: 10.1016/j.aquatox.2018.04.003. Epub 2018 
      Apr 18.