PMID- 29729912
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 101
IP  - 8
DP  - 2018 Aug
TI  - Influence of supplementing a methionine derivative, N-acetyl-l-methionine, in 
      dairy diets on production and ruminal fermentation by lactating cows during early 
      to mid lactation.
PG  - 7082-7094
LID - S0022-0302(18)30406-5 [pii]
LID - 10.3168/jds.2017-14130 [doi]
AB  - The present study investigated production responses and ruminal fermentation 
      characteristics of lactating dairy cows when supplemented with N-acetyl-l-Met 
      (NALM) as a source of rumen-protected Met in metabolizable protein (MP)-deficient 
      (MPD) or MP-adequate diet (MPA). Eight lactating dairy cows (53 +/- 10.4 d in milk, 
      average +/- standard deviation) were blocked by parity and days in milk, and the 
      experiment was performed in a replicated 4 x 4 Latin square design. Within each 
      square, cows were randomly assigned to a sequence of 4 diets during each of the 
      four 21-d periods (14 d of treatment adaptation and 7 d of data collection and 
      sampling). A 2 x 2 factorial arrangement was used; MPD or MPA was combined 
      without or with NALM: MPD without NALM, MPD with NALM (MPD+NALM), MPA without 
      NALM, and MPA with NALM (MPA+NALM). A NALM product was supplemented in the 
      MPD+NALM and the MPA+NALM at 30 g/cow per d. Supplementation of NALM did not 
      affect dry matter intake (DMI) and milk yield regardless of MP concentration. In 
      addition, supplementing NALM resulted in a similar milk true protein 
      concentration and yield. In contrast, NALM supplementation increased milk fat 
      concentration and yield and 3.5% fat-corrected milk yield and tended to increase 
      energy-corrected milk yield regardless of MP difference. Additionally, trends 
      were observed for increased 3.5% fat-corrected milk yield/DMI and 
      energy-corrected milk yield/DMI, and the positive effects were greater under the 
      MPA than the MPD diet, resulting in trends toward interactions between MP and 
      NALM. Dietary treatments had similar effects on ruminal fermentation 
      characteristics and microbial protein yield. Plasma concentration of Met 
      increased under the MPD but not the MPA diet, leading to an MP x NALM 
      interaction. Overall results in the current study suggest that NALM exerted a 
      minor influence on ruminal metabolism, but increased milk fat concentration, 
      resulting in increases in milk fat yield and feed efficiency. Yet, potential 
      effects of NALM on intermediary metabolism between the gastrointestinal tract, 
      the liver, and the mammary gland need to be explored to understand utilization 
      efficiency for production of dairy cows.
CI  - Copyright (c) 2018 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Fagundes, M A
AU  - Fagundes MA
AD  - Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 
      Logan 84322.
FAU - Yang, S Y
AU  - Yang SY
AD  - Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 
      Logan 84322.
FAU - Eun, J-S
AU  - Eun JS
AD  - Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 
      Logan 84322; CJ CheilJedang Research Institute of Biotechnology, Suwon, South 
      Korea 16495. Electronic address: jongsu.eun@cj.net.
FAU - Hall, J O
AU  - Hall JO
AD  - Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 
      Logan 84322.
FAU - Moon, J O
AU  - Moon JO
AD  - CJ CheilJedang Research Institute of Biotechnology, Suwon, South Korea 16495.
FAU - Park, J S
AU  - Park JS
AD  - CJ CheilJedang Research Institute of Biotechnology, Suwon, South Korea 16495.
LA  - eng
PT  - Journal Article
DEP - 20180503
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - *Animal Feed
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Cattle
MH  - *Diet
MH  - Digestion
MH  - Female
MH  - Fermentation
MH  - Lactation/*physiology
MH  - Methionine/*administration & dosage
MH  - Milk
MH  - Rumen/*metabolism
OTO - NOTNLM
OT  - N-acetyl-l-methionine
OT  - feed efficiency
OT  - lactational performance
OT  - milk fat concentration
EDAT- 2018/05/08 06:00
MHDA- 2019/02/26 06:00
CRDT- 2018/05/07 06:00
PHST- 2017/11/12 00:00 [received]
PHST- 2018/03/25 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2018/05/07 06:00 [entrez]
AID - S0022-0302(18)30406-5 [pii]
AID - 10.3168/jds.2017-14130 [doi]
PST - ppublish
SO  - J Dairy Sci. 2018 Aug;101(8):7082-7094. doi: 10.3168/jds.2017-14130. Epub 2018 
      May 3.