PMID- 29730445
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 96
DP  - 2018 Jul
TI  - Chemical applicability domain of the local lymph node assay (LLNA) for skin 
      sensitisation potency. Part 4. Quantitative correlation of LLNA potency with 
      human potency.
PG  - 76-84
LID - S0273-2300(18)30131-4 [pii]
LID - 10.1016/j.yrtph.2018.04.022 [doi]
AB  - Prediction of skin sensitisation potential and potency by non-animal methods is 
      the target of many active research programmes. Although the aim is to predict 
      sensitisation potential and potency in humans, data from the murine local lymph 
      node assay (LLNA) constitute much the largest source of quantitative data on in 
      vivo skin sensitisation. The LLNA has been the preferred in vivo method for 
      identification of skin sensitising chemicals and as such is potentially valuable 
      as a benchmark for assessment of non-animal approaches. However, in common with 
      all predictive test methods, the LLNA is subject to false positives and false 
      negatives with an overall level of accuracy said variously to be approximately 
      80% or 90%. It is also necessary to consider the extent to which, for true 
      positives, LLNA potency correlates with human potency. In this paper LLNA potency 
      and human potency are compared so as to express quantitatively the correlation 
      between them, and reasons for non-agreement between LLNA and human potency are 
      analysed. This leads to a better definition of the applicability domain of the 
      LLNA, within which LLNA data can be used confidently to predict human potency and 
      as a benchmark to assess the performance of non-animal approaches.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Roberts, David W
AU  - Roberts DW
AD  - School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 
      Liverpool L3 3AF, United Kingdom. Electronic address: d.w.roberts@ljmu.ac.uk.
FAU - Api, Anne Marie
AU  - Api AM
AD  - Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff 
      Lake, NJ 07677, United States.
LA  - eng
PT  - Journal Article
DEP - 20180503
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
SB  - IM
MH  - Dermatitis, Allergic Contact/*immunology
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Skin/*immunology
OTO - NOTNLM
OT  - Applicability domains
OT  - HRIPT
OT  - LLNA
OT  - Quantitative correlation
EDAT- 2018/05/08 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/05/07 06:00
PHST- 2018/01/25 00:00 [received]
PHST- 2018/04/23 00:00 [revised]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/05/07 06:00 [entrez]
AID - S0273-2300(18)30131-4 [pii]
AID - 10.1016/j.yrtph.2018.04.022 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2018 Jul;96:76-84. doi: 10.1016/j.yrtph.2018.04.022. 
      Epub 2018 May 3.