PMID- 29732146
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 8
IP  - 5
DP  - 2018 May
TI  - Oxidative stress and kidney injury in trans-radial catheterization.
PG  - 417-425
LID - 10.3892/br.2018.1071 [doi]
AB  - Oxidative stress is linked to coronary artery disease and is a major mechanism in 
      contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) 
      with minimized peri-procedural bleeding is expected to reduce acute kidney injury 
      incidence. In the present study, oxidative stress patterns observed in radial CA 
      and their associations with early manifestations of kidney injury are described. 
      A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched 
      patients undergoing computed tomography for myoskeletal reasons were enrolled. 
      Reduced glutathione, catalase, thiobarbituric acid reactive species (TBARS) 
      levels and total anti-oxidant status were measured at various time points 
      postangiography. In ischemic patients baseline TBARS levels were 2-fold lower 
      compared to controls, while carbonyls levels were 35% higher. Glutathione was 
      almost 4-fold lower than the control group. Glutathione and lipid peroxidation in 
      ischemic patients gradually increased after contrast medium administration and 
      reached 180% (P<0.001) and 20% (P=0.021) after 4-6 h, respectively. Four patients 
      presented early evidence of contrast-induced nephropathy postangiography, while 
      no control patient developed acute kidney injury. In the multiple logistic 
      regression analysis, only the creatinine levels at baseline influenced the 
      frequency of early contrast-induced nephropathy development (beta =0.36, 95% CI: 
      0.285-0.438, P=0.01). Glutathione low levels were dominant in the baseline values 
      of ischemic patients who developed contrast-induced nephropathy. Glutathione 
      levels rapidly increased while protein oxidation decreased at the expense of 
      lipid peroxidation. In conclusion, early oxidative stress changes occur in 
      trans-radial CA patients with a mild profile, sufficient to mobilize patient 
      antioxidant defenses.
FAU - Tsarouhas, Konstantinos
AU  - Tsarouhas K
AD  - Department of Cardiology, University Hospital of Larissa, 41110 Larissa, Greece.
FAU - Tsitsimpikou, Christina
AU  - Tsitsimpikou C
AD  - General Chemical State Laboratory of Greece, 11521 Athens, Greece.
FAU - Papantoni, Xrisoula
AU  - Papantoni X
AD  - Department of Biochemistry-Biotechnology, School of Health Sciences, University 
      of Thessaly, 41500 Larissa, Greece.
FAU - Lazaridou, Dimitra
AU  - Lazaridou D
AD  - Department of Biochemistry-Biotechnology, School of Health Sciences, University 
      of Thessaly, 41500 Larissa, Greece.
FAU - Koutouzis, Michael
AU  - Koutouzis M
AD  - 2nd Department of Cardiology, Red Cross Hospital, 11526 Athens, Greece.
FAU - Mazzaris, Savvas
AU  - Mazzaris S
AD  - Department of Cardiology, Amalia Fleming General Hospital, 15127 Athens, Greece.
FAU - Rezaee, Ramin
AU  - Rezaee R
AD  - Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mamoulakis, Charalambos
AU  - Mamoulakis C
AD  - Department of Urology, Medical School, University of Crete, 70013 Heraklion, 
      Crete, Greece.
FAU - Georgoulias, Panagiotis
AU  - Georgoulias P
AD  - Department of Nuclear Medicine, University Hospital of Larissa, 41110 Larissa, 
      Greece.
FAU - Nepka, Charitini
AU  - Nepka C
AD  - Department of Pathology, University Hospital of Larissa, 41110 Larissa, Greece.
FAU - Rentoukas, Elias
AU  - Rentoukas E
AD  - Department of Cardiology, Amalia Fleming General Hospital, 15127 Athens, Greece.
FAU - Kyriakides, Zenon
AU  - Kyriakides Z
AD  - 2nd Department of Cardiology, Red Cross Hospital, 11526 Athens, Greece.
FAU - Tsatsakis, Aristidis
AU  - Tsatsakis A
AD  - Laboratory of Toxicology, Medical School, University of Crete, 70013 Heraklion, 
      Crete, Greece.
FAU - Spandidos, Demetrios A
AU  - Spandidos DA
AD  - Department of Virology, Medical School, University of Crete, 70013 Heraklion, 
      Crete, Greece.
FAU - Kouretas, Demetrios
AU  - Kouretas D
AD  - Department of Biochemistry-Biotechnology, School of Health Sciences, University 
      of Thessaly, 41500 Larissa, Greece.
LA  - eng
PT  - Journal Article
DEP - 20180228
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC5920711
OTO - NOTNLM
OT  - contrast-induced nephropathy
OT  - oxidative stress
OT  - trans-radial catheterization
EDAT- 2018/05/08 06:00
MHDA- 2018/05/08 06:01
PMCR- 2018/02/28
CRDT- 2018/05/08 06:00
PHST- 2018/01/26 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/05/08 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/05/08 06:01 [medline]
PHST- 2018/02/28 00:00 [pmc-release]
AID - BR-0-0-1071 [pii]
AID - 10.3892/br.2018.1071 [doi]
PST - ppublish
SO  - Biomed Rep. 2018 May;8(5):417-425. doi: 10.3892/br.2018.1071. Epub 2018 Feb 28.