PMID- 29733330
OWN - NLM
STAT- MEDLINE
DCOM- 20191101
LR  - 20200306
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 74
IP  - 2
DP  - 2019 Jan 16
TI  - Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis 
      Are Transmitted Independent of NQO1.
PG  - 155-162
LID - 10.1093/gerona/gly112 [doi]
AB  - Caloric restriction (CR) is the most potent nonpharmacological intervention known 
      to both protect against carcinogenesis and delay aging in laboratory animals. 
      There is a growing number of anticarcinogens and CR mimetics that activate 
      NAD(P)H:quinone oxidoreductase 1 (NQO1). We have previously shown that NQO1, an 
      antioxidant enzyme that acts as an energy sensor through modulation of 
      intracellular redox and metabolic state, is upregulated by CR. Here, we used 
      NQO1-knockout (KO) mice to investigate the role of NQO1 in both the aging process 
      and tumor susceptibility, specifically in the context of CR. We found that NQO1 
      is not essential for the beneficial effects of CR on glucose homeostasis, 
      physical performance, metabolic flexibility, life-span extension, and (unlike our 
      previously observation with Nrf2) chemical-induced tumorigenesis.
FAU - Diaz-Ruiz, Alberto
AU  - Diaz-Ruiz A
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
AD  - Nutritional Interventions Group, Precision Nutrition and Aging, Institute IMDEA 
      Food, Madrid, Spain.
FAU - Di Francesco, Andrea
AU  - Di Francesco A
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
FAU - Carboneau, Bethany A
AU  - Carboneau BA
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
FAU - Levan, Sophia R
AU  - Levan SR
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
FAU - Pearson, Kevin J
AU  - Pearson KJ
AD  - Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington.
FAU - Price, Nathan L
AU  - Price NL
AD  - Vascular Biology and Therapeutics Program, Yale University School of Medicine, 
      New Haven, CT.
AD  - Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of 
      Comparative Medicine, Yale University School of Medicine, New Haven, CT.
FAU - Ward, Theresa M
AU  - Ward TM
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
FAU - Bernier, Michel
AU  - Bernier M
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
FAU - de Cabo, Rafael
AU  - de Cabo R
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
AD  - Nutritional Interventions Group, Precision Nutrition and Aging, Institute IMDEA 
      Food, Madrid, Spain.
FAU - Mercken, Evi M
AU  - Mercken EM
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, Maryland.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Biomarkers, Tumor)
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (Nqo1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/metabolism
MH  - *Body Composition
MH  - Caloric Restriction/*adverse effects
MH  - Carcinogenesis
MH  - Immunoblotting
MH  - *Longevity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - NAD(P)H Dehydrogenase (Quinone)/*metabolism
MH  - Neoplasms, Experimental/etiology/metabolism/*prevention & control
MH  - *Oxidative Stress
PMC - PMC6599277
EDAT- 2018/05/08 06:00
MHDA- 2019/11/02 06:00
PMCR- 2019/05/04
CRDT- 2018/05/08 06:00
PHST- 2017/12/08 00:00 [received]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/11/02 06:00 [medline]
PHST- 2018/05/08 06:00 [entrez]
PHST- 2019/05/04 00:00 [pmc-release]
AID - 4992527 [pii]
AID - gly112 [pii]
AID - 10.1093/gerona/gly112 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):155-162. doi: 
      10.1093/gerona/gly112.