PMID- 29733513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221110
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 7
IP  - 7
DP  - 2018 Jul
TI  - Radiotherapy vs surgery for T1-2N0M0 laryngeal squamous cell carcinoma: A 
      population-based and propensity score matching study.
PG  - 2837-2847
LID - 10.1002/cam4.1525 [doi]
AB  - There are conflicting reports about whether radiotherapy or surgery is optimal 
      for early-stage laryngeal squamous cell carcinoma (LSCC), although both have 
      recently been recommended. Patients with T1-2N0M0 LSCC in the population-based 
      SEER database who underwent radiotherapy or surgery were reviewed. Propensity 
      score matching was used to eliminate the baseline variations. After matching, 
      1913 pairs of patients were included. Overall, patients who received radiotherapy 
      had worse cancer-specific survival than patients with surgery. After 
      stratification, the survival in patients who received radiotherapy was worse with 
      respect to the following characteristics: </=60 years of age; T1a glottis cancer; 
      well-differentiated tumors; and with married status. In other patients, survival 
      outcomes were similar in patients who received radiotherapy and underwent 
      surgery. Our results indicate that radiotherapy is not preferable in early-stage 
      LSCC patients who are </=60 years of age, have T1a glottis cancer or 
      well-differentiated tumors, or are married. In other patients, both radiotherapy 
      and surgery are comparable. However, our results cannot be a reference before 
      controlled, prospective trials are performed.
CI  - (c) 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Zhan, Cheng
AU  - Zhan C
AUID- ORCID: 0000-0001-8745-9276
AD  - Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
FAU - Yang, Xiaodong
AU  - Yang X
AD  - Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
FAU - Song, Xinmao
AU  - Song X
AD  - Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, 
      China.
FAU - Yan, Li
AU  - Yan L
AUID- ORCID: 0000-0002-0697-7838
AD  - Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, 
      China.
LA  - eng
GR  - 81703023/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20180507
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
SB  - IM
PMC - PMC6051150
OTO - NOTNLM
OT  - SEER
OT  - laryngeal squamous cell carcinoma
OT  - radiotherapy
OT  - surgery
EDAT- 2018/05/08 06:00
MHDA- 2018/05/08 06:01
PMCR- 2018/05/07
CRDT- 2018/05/08 06:00
PHST- 2018/04/07 00:00 [revised]
PHST- 2018/01/15 00:00 [received]
PHST- 2018/04/09 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/05/08 06:01 [medline]
PHST- 2018/05/08 06:00 [entrez]
PHST- 2018/05/07 00:00 [pmc-release]
AID - CAM41525 [pii]
AID - 10.1002/cam4.1525 [doi]
PST - ppublish
SO  - Cancer Med. 2018 Jul;7(7):2837-2847. doi: 10.1002/cam4.1525. Epub 2018 May 7.