PMID- 29733851
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 194
DP  - 2018 Oct 1
TI  - Fish oil supplementation reverses behavioral and neurochemical alterations 
      induced by swimming exercise in rats.
PG  - 95-102
LID - S0031-9384(18)30224-5 [pii]
LID - 10.1016/j.physbeh.2018.05.001 [doi]
AB  - Diet and exercise are known to affect learning and memory. However, the effects 
      of these interventions in the brain under development remains to be better 
      investigated as the effects of high-intensity exercise. Moreover, it is still 
      unclear how long the influence of diet and exercise lasts after the interventions 
      are ceased. To investigate this, juvenile Wistar rats (30 days old) were 
      supplemented with fish oil rich in polyunsaturated fatty acids (PUFAs) and 
      performed swimming training for 50 days, 45 min per day, 5 times/week. The 
      animals were assessed for locomotor activity with the open field test and for 
      spatial memory with the object location task. To investigate neurochemical 
      parameters such as fatty acids incorporation within the plasma membrane and 
      brain-derived neurotrophic factor (BDNF) levels, the animals were euthanized, and 
      the hippocampus dissected. These investigations were made at the end of the 
      supplementation and exercise protocols and 21 days after the protocol has ended. 
      Results indicate that high-intensity exercise impaired the spatial memory and 
      decreased the levels of BDNF. Although supplementation led to PUFAs incorporation 
      in plasma membrane, it did not prevent the harmful effect of exercise on memory. 
      After 21 days of interruption, we observed that the supplementation reversed not 
      only the deleterious effect of exercise on memory but also increased the BDNF 
      levels. These results point to a complex influence of diet and exercise on 
      spatial memory of juvenile rats, persisting after 21 days of interruption.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Dos Santos, Fabiola Vila
AU  - Dos Santos FV
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990 Curitiba, PR, Brazil.
FAU - Targa, Adriano D S
AU  - Targa ADS
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990 Curitiba, PR, Brazil. Electronic address: 
      adrianotargads@gmail.com.
FAU - Hammerschmidt, Ivilin
AU  - Hammerschmidt I
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990 Curitiba, PR, Brazil.
FAU - Zanata, Silvio M
AU  - Zanata SM
AD  - Laboratorio de Neurobiologia, Departamento de Patologia Basica, Universidade 
      Federal do Parana, 81.531-990 Curitiba, PR, Brazil.
FAU - Maia, Flavia G
AU  - Maia FG
AD  - Laboratorio de Neurobiologia, Departamento de Patologia Basica, Universidade 
      Federal do Parana, 81.531-990 Curitiba, PR, Brazil.
FAU - Visentainer, Jesui V
AU  - Visentainer JV
AD  - Laboratorio de Quimica de Alimentos, Departamento de Quimica, Universidade 
      Estadual de Maringa, 87.020-900 Maringa, PR, Brazil.
FAU - Santos Junior, Oscar O
AU  - Santos Junior OO
AD  - Laboratorio de Quimica de Alimentos, Departamento de Quimica, Universidade 
      Estadual de Maringa, 87.020-900 Maringa, PR, Brazil.
FAU - da Costa, Belmira Andrade
AU  - da Costa BA
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia e Farmacologia, 
      Universidade Federal de Pernambuco, 50.670-901 Recife, PE, Brazil.
FAU - Lagranha, Claudia J
AU  - Lagranha CJ
AD  - Nucleo de Eduacacao Fisica e Ciencias do Esporte, Universidade Federal de 
      Pernambuco, 50.670-901 Recife, PE, Brazil.
FAU - Ferraz, Anete C
AU  - Ferraz AC
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990 Curitiba, PR, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180504
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Fish Oils)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Membrane/metabolism
MH  - Dietary Supplements
MH  - Fatty Acids, Unsaturated/*metabolism
MH  - Fish Oils/pharmacology/*therapeutic use
MH  - Hippocampus/drug effects/metabolism
MH  - Locomotion/physiology
MH  - Male
MH  - Memory Disorders/*diet therapy
MH  - Physical Conditioning, Animal/physiology
MH  - Rats
MH  - Spatial Memory/drug effects
MH  - Swimming/*physiology/*psychology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Exercise
OT  - Fish oil supplementation
OT  - Spatial memory
EDAT- 2018/05/08 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/05/08 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/04/12 00:00 [revised]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/05/08 06:00 [entrez]
AID - S0031-9384(18)30224-5 [pii]
AID - 10.1016/j.physbeh.2018.05.001 [doi]
PST - ppublish
SO  - Physiol Behav. 2018 Oct 1;194:95-102. doi: 10.1016/j.physbeh.2018.05.001. Epub 
      2018 May 4.