PMID- 29733875
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 298
DP  - 2018 Dec 1
TI  - Neuroinflammation markers and methyl alcohol induced toxic brain damage.
PG  - 60-69
LID - S0378-4274(18)30175-9 [pii]
LID - 10.1016/j.toxlet.2018.05.001 [doi]
AB  - Methyl alcohol intoxication is a global problem with high mortality and long-term 
      visual sequelae and severe brain damage in survivors. The role of 
      neuroinflammation in the mechanisms of methyl alcohol-induced toxic brain damage 
      has not been well studied. We measured the acute concentrations and dynamics of 
      lipoxins LxA4 and LxB4 and the interleukins IL-4, IL-5, IL-9, IL-10, and IL-13 in 
      the serum of patients treated with methyl alcohol poisoning and the follow-up 
      concentrations in survivors two years after discharge from the hospital. A series 
      of acute measurements was performed in 28 hospitalized patients (mean age 
      54.2 +/- 5.2 years, mean observation time 88 +/- 20 h) and the follow-up measurements 
      were performed in 36 subjects who survived poisoning (including 12/28 survivors 
      from the acute group). Visual evoked potentials (VEP) and magnetic resonance 
      imaging of the brain (MRI) were performed to detect long-term visual and brain 
      sequelae of intoxication. The acute concentrations of inflammatory mediators were 
      higher than the follow-up concentrations: LxA4, 62.0 +/- 6.0 vs. 30.0 +/- 5.0 pg/mL; 
      LxB4, 64.0 +/- 7.0 vs. 34.0 +/- 4.0 pg/mL; IL-4, 29.0 +/- 4.0 vs. 15.0 +/- 1.0 pg/mL; 
      IL-5, 30.0 +/- 4.0 vs. 13.0 +/- 1.0 pg/mL; IL-9, 30.0 +/- 4.0 vs. 13.0 +/- 1.0 pg/mL; 
      IL-10, 38.0 +/- 5.0 vs. 16.0 +/- 1.0 pg/mL; IL-13, 35.0 +/- 4.0 vs. 14.0 +/- 1.0 pg/mL 
      (all p < 0.001). The patients with higher follow-up IL-5 concentration had 
      prolonged latency P1 (r = 0.413; p = 0.033) and lower amplitude N1P1 (r = -0.498; 
      p = 0.010) of VEP. The higher follow-up IL-10 concentration was associated with 
      MRI signs of brain necrotic damage (r = 0.533; p = 0.001) and brain hemorrhage 
      (r = 0.396; p = 0.020). Our findings suggest that neuroinflammation plays an 
      important role in the mechanisms of toxic brain damage in acute methyl alcohol 
      intoxication.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zakharov, Sergey
AU  - Zakharov S
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic; Toxicological Information 
      Centre, General University Hospital, Na Bojisti 1, 12000, Prague, Czech Republic. 
      Electronic address: sergey.zakharov@vfn.cz.
FAU - Hlusicka, Jiri
AU  - Hlusicka J
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic; Toxicological Information 
      Centre, General University Hospital, Na Bojisti 1, 12000, Prague, Czech Republic.
FAU - Nurieva, Olga
AU  - Nurieva O
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic.
FAU - Kotikova, Katerina
AU  - Kotikova K
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic.
FAU - Lischkova, Lucie
AU  - Lischkova L
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic; Toxicological Information 
      Centre, General University Hospital, Na Bojisti 1, 12000, Prague, Czech Republic.
FAU - Kacer, Petr
AU  - Kacer P
AD  - Biocev, First Faculty of Medicine, Charles University, Prumyslova 595, 25250, 
      Vestec, Czech Republic.
FAU - Kacerova, Tereza
AU  - Kacerova T
AD  - Biocev, First Faculty of Medicine, Charles University, Prumyslova 595, 25250, 
      Vestec, Czech Republic.
FAU - Urban, Pavel
AU  - Urban P
AD  - First Faculty of Medicine, Charles University, Department of Occupational 
      Medicine, Na Bojisti 1, 12000, Prague, Czech Republic; Centre for Industrial 
      Hygiene and Occupational Medicine, National Institute of Public Health, Srobarova 
      49/48, 10000, Prague, Czech Republic.
FAU - Vaneckova, Manuela
AU  - Vaneckova M
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Department of Radiology, U Nemocnice 499/2, 12808, Prague, Czech Republic.
FAU - Seidl, Zdenek
AU  - Seidl Z
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Department of Radiology, U Nemocnice 499/2, 12808, Prague, Czech Republic.
FAU - Diblik, Pavel
AU  - Diblik P
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Department of Ophthalmology, U Nemocnice 499/2, 12808, Prague, Czech Republic.
FAU - Kuthan, Pavel
AU  - Kuthan P
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Department of Ophthalmology, U Nemocnice 499/2, 12808, Prague, Czech Republic.
FAU - Heissigerova, Jarmila
AU  - Heissigerova J
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Department of Ophthalmology, U Nemocnice 499/2, 12808, Prague, Czech Republic.
FAU - Lesovsky, Jiri
AU  - Lesovsky J
AD  - Toxicological Information Centre, General University Hospital, Na Bojisti 1, 
      12000, Prague, Czech Republic.
FAU - Rulisek, Jan
AU  - Rulisek J
AD  - First Faculty of Medicine, Charles University and General University Hospital, 
      Clinic of Anesthesiology, Resuscitation and Intensive Medicine, U Nemocnice 
      499/2, 12808, Prague, Czech Republic.
FAU - Vojtova, Lucie
AU  - Vojtova L
AD  - Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of 
      Medicine, Charles University and General University Hospital, Katerinska 32, 
      12108, Prague, Czech Republic.
FAU - Hubacek, Jaroslav A
AU  - Hubacek JA
AD  - Centre for Experimental Medicine, Institute for Clinical and Experimental 
      Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.
FAU - Navratil, Tomas
AU  - Navratil T
AD  - Toxicological Information Centre, General University Hospital, Na Bojisti 1, 
      12000, Prague, Czech Republic; Department of Biomimetic Electrochemistry, J. 
      Heyrovsky Institute of Physical Chemistry of the AS CR, v.v.i, Dolejskova 2155/3, 
      18200, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
DEP - 20180504
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain/diagnostic imaging/drug effects/physiopathology
MH  - Cytokines/*blood
MH  - Evoked Potentials, Visual/drug effects
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methanol/*poisoning
MH  - Middle Aged
MH  - Neurotoxicity Syndromes/*blood/diagnosis/mortality/physiopathology
MH  - Prospective Studies
MH  - Reaction Time/drug effects
MH  - Time Factors
OTO - NOTNLM
OT  - CNS damage
OT  - Interleukins
OT  - Lipoxins
OT  - Methyl alcohol poisoning
OT  - Neuroinflammation
OT  - Non-traumatic brain injury
EDAT- 2018/05/08 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/05/08 06:00
PHST- 2018/02/17 00:00 [received]
PHST- 2018/04/22 00:00 [revised]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/05/08 06:00 [entrez]
AID - S0378-4274(18)30175-9 [pii]
AID - 10.1016/j.toxlet.2018.05.001 [doi]
PST - ppublish
SO  - Toxicol Lett. 2018 Dec 1;298:60-69. doi: 10.1016/j.toxlet.2018.05.001. Epub 2018 
      May 4.