PMID- 29734489
OWN - NLM
STAT- MEDLINE
DCOM- 20191028
LR  - 20191028
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 48
IP  - 6
DP  - 2018 Dec
TI  - Diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging 
      in the assessment of the dynamic status of myocardial perfusion.
PG  - 1602-1609
LID - 10.1002/jmri.26179 [doi]
AB  - BACKGROUND: Acute myocardial infarction (AMI) is a major cause of morbidity and 
      mortality worldwide and places a significant financial burden on our society. 
      PURPOSE: To determine the feasibility of cardiac intravoxel incoherent motion 
      (IVIM) in the consecutive evaluation of myocardial perfusion in myocardial 
      infarction patients postpercutaneous coronary intervention (PCI) and to 
      investigate the dynamic biological phenomena in myocardial perfusion after AMI. 
      STUDY TYPE: Prospective observational study. POPULATION: Twenty ST-segment 
      elevation myocardial infarction (STEMI) patients after reperfusion therapy and 12 
      healthy volunteers served as controls. FIELD STRENGTH/SEQUENCE: Cardiac MRI at 
      3T, including steady-state free precession (SSFP) cine imaging, T(2) -short time 
      inversion recovery (T(2) -STIR), late gadolinium enhancement (LGE), T(2) mapping, 
      and IVIM diffusion-weighted imaging (DWI) were performed. ASSESSMENT: Myocardial 
      T(2) value and IVIM-DWI-associated parameters (ADC(fast) , ADC(slow) , and f 
      value) of the infarcted myocardium at different timepoints, remote myocardium, 
      and normal myocardium were analyzed by two experienced radiologists. STATISTICAL 
      TESTS: Independent sample's t-test, Pearson's, and Spearman's correlation and 
      interobserver variability were applied. P </= 0.05 was considered significant. 
      RESULTS: The T(2) value in ischemic myocardium measured on day 3 (73.58 +/- 4.37 
      msec) was greater than at any other timepoint (24 hours, day 7, day 30; 
      66.66 +/- 4.71 msec, 68.36 +/- 4.18 msec, 64.98 +/- 5.39 msec, respectively, 
      P < 0.001). ADC(fast) and f values were significantly lower in ischemic 
      myocardium than in the remote myocardium as well. The f value in ischemic 
      myocardium at day 3 (0.0989 +/- 0.02) was lower than at any other timepoint (24 
      hours, 7 day, 30 day; 0.1203 +/- 0.02, 0.1109 +/- 0.02, 0.1213 +/- 0.02, respectively, 
      P < 0.001. DATA CONCLUSION: This preliminary study demonstrated that a dynamic 
      process exists in the status of myocardial edema and myocardial perfusion in MI 
      patients after PCI. The findings suggest myocardial perfusion would be best 
      evaluated between day 3 and day 7. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 
      2 J. Magn. Reson. Imaging 2018;48:1602-1609.
CI  - (c) 2018 International Society for Magnetic Resonance in Medicine.
FAU - An, Dong-Aolei
AU  - An DA
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Chen, Bing-Hua
AU  - Chen BH
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Rui-Wu
AU  - Rui-Wu
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Shi, Ruo-Yang
AU  - Shi RY
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Bu, Jun
AU  - Bu J
AD  - Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Ge, Heng
AU  - Ge H
AD  - Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Hu, Jiani
AU  - Hu J
AD  - Department of Radiology, Wayne State University, Detroit, Michigan, USA.
FAU - Xu, Jian-Rong
AU  - Xu JR
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wu, Lian-Ming
AU  - Wu LM
AUID- ORCID: 0000-0001-7381-5436
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
LA  - eng
GR  - 2017YQ031/Shanghai Municipal Commission of Health and Family Planning excellent 
      young talent program/International
GR  - PYEY16-001/Renji Hospital Clinical Training Fund/International
GR  - 201559/Shanghai talent development fund/International
GR  - Shanghai young doctor training program/International
GR  - Shanghai Jiao Tong University "Chen-Xing B" program/International
GR  - YG2017QN44/Shanghai Jiao Tong University medical-engineering cross 
      fund/International
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180507
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Edema
MH  - Female
MH  - Gadolinium
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Motion
MH  - Myocardial Infarction/*diagnostic imaging
MH  - Myocardial Ischemia/diagnostic imaging
MH  - *Myocardial Perfusion Imaging
MH  - Myocardium/pathology
MH  - Percutaneous Coronary Intervention
MH  - Prospective Studies
OTO - NOTNLM
OT  - AMI
OT  - IVIM
OT  - T2 mapping
OT  - late gadolinium enhanced imaging
EDAT- 2018/05/08 06:00
MHDA- 2019/10/29 06:00
CRDT- 2018/05/08 06:00
PHST- 2018/02/14 00:00 [received]
PHST- 2018/04/16 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/10/29 06:00 [medline]
PHST- 2018/05/08 06:00 [entrez]
AID - 10.1002/jmri.26179 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2018 Dec;48(6):1602-1609. doi: 10.1002/jmri.26179. Epub 
      2018 May 7.